Combining molecular and imaging metrics in cancer: Radiogenomics Review


Authors: Lo Gullo, R.; Daimiel, I.; Morris, E. A.; Pinker, K.
Review Title: Combining molecular and imaging metrics in cancer: Radiogenomics
Abstract: Background: Radiogenomics is the extension of radiomics through the combination of genetic and radiomic data. Because genetic testing remains expensive, invasive, and time-consuming, and thus unavailable for all patients, radiogenomics may play an important role in providing accurate imaging surrogates which are correlated with genetic expression, thereby serving as a substitute for genetic testing. Main body: In this article, we define the meaning of radiogenomics and the difference between radiomics and radiogenomics. We provide an up-to-date review of the radiomics and radiogenomics literature in oncology, focusing on breast, brain, gynecological, liver, kidney, prostate and lung malignancies. We also discuss the current challenges to radiogenomics analysis. Conclusion: Radiomics and radiogenomics are promising to increase precision in diagnosis, assessment of prognosis, and prediction of treatment response, providing valuable information for patient care throughout the course of the disease, given that this information is easily obtainable with imaging. Larger prospective studies and standardization will be needed to define relevant imaging biomarkers before they can be implemented into the clinical workflow. © 2019, The Author(s).
Keywords: molecular profiling; precision medicine; radiogenomics; radiomics
Journal Title: Insights into Imaging
Volume: 11
ISSN: 1869-4101
Publisher: SpringerOpen  
Date Published: 2020-01-01
Start Page: 1
Language: English
DOI: 10.1186/s13244-019-0795-6
PROVIDER: scopus
PMCID: PMC6942081
PUBMED: 31901171
DOI/URL:
Notes: Source: Scopus
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  1. Elizabeth A Morris
    341 Morris