Organization of the human and mouse low-affinity FcγR genes: Duplication and recombination Journal Article
| Authors: | Qiu, W. Q.; de Bruin, D.; Brownstein, B. H.; Pearse, R.; Ravetch, J. V. |
| Article Title: | Organization of the human and mouse low-affinity FcγR genes: Duplication and recombination |
| Abstract: | Receptors for immunoglobulin G immune complexes (FcγRII and FcγRIII) are expressed on most hematopoietic cells and show much structural and functional diversity. In order to determine the genetic basis for this diversity, a family of genes encoding the human and mouse receptors was isolated and characterized. Humans have five distinct genes for low-affinity FcγRs, in contrast to two in the mouse. With the use of yeast artificial chromosomes, the genes encoding the human receptors were oriented and linked, which established the structure of this complex locus. Comparison of the human and mouse genes generated a model for the evolutionary amplification of this locus. |
| Keywords: | human cell; mutation; exons; nonhuman; comparative study; animal cell; mouse; animal; mice; spleen; introns; animalia; molecular sequence data; immunoglobulin g; recombination, genetic; base sequence; fc receptor; receptors, igg; genome, human; antigens, differentiation; gene structure; multigene family; antigen antibody complex; immunoglobulin receptor; genetic organization; restriction mapping; receptors, fc; blotting, southern; human; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Science |
| Volume: | 248 |
| Issue: | 4956 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 1990-05-11 |
| Start Page: | 732 |
| End Page: | 735 |
| Language: | English |
| DOI: | 10.1126/science.2139735 |
| PUBMED: | 2139735 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 January 2020 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work