Changes in (31)P nuclear magnetic resonance with tumor growth in radioresistant and radiosensitive tumors Journal Article

  


Authors: Koutcher, J. A.; Alfieri, A. A.; Barnett, D. C.; Cowburn, D. C.; Kornblith, A. B.; Kim, J. H.
Article Title: Changes in (31)P nuclear magnetic resonance with tumor growth in radioresistant and radiosensitive tumors
Abstract: In vivo 31P nuclear magnetic resonance (31P NMR) spectroscopy has been used to compare metabolic profile with tumor radiosensitivity. A radioresistant mammary carcinoma (MCa) and a radiosensitive methylcholanthrene-induced fibrosarcoma (Meth-A) were studied by 31P NMR spectroscopy in the tumor volume range of approximately 100-1200 mm3. The MCa showed a constant pH in this volume range; the ratio of phosphocreatine to inorganic phosphate (PCr/P(i)) for 160-300 mm3 tumors was 0.33 ± 0.11 (mean ± standard deviation) and did not change (0.29 ± .09) for tumors in the volume range of 600-1200 mm3. In comparison, the Meth-A showed a decrease in tumor pH as volume increased from 160-300 mm3 (pH 7.16 ± .04) to 600-1200 mm3 (pH 6.94 ± .07). Tumor PCr/P(i) decreased from 0.70 ± .16 (160-300 mm3) to 0.33 ± .16 (600-1200 mm3). The radiation doses for control of MCa-induced tumors in 50% of the treated tumors ranged from 65 (150-250 mm3) to 71 Gy (1000-1300 mm3) and for the Meth-A-induced tumors ranged from 35 (150-250 mm3) to 38 Gy (1000-1300 mm3). These results sugest that 31P NMR spectra may be a qualitative predictor of tumor hypoxia, although further studies of human and rodent tumors are necessary to support this hypothesis.
Keywords: radiation dose; methodology; mouse; animal; metabolism; mice; animal experiment; ph; pathology; animalia; hypoxia; fibrosarcoma; diagnostic agent; breast carcinoma; magnetic resonance spectroscopy; nuclear magnetic resonance spectroscopy; radiosensitivity; experimental neoplasm; rodentia; neoplasm transplantation; tumor growth; nuclear magnetic resonance; hydrogen-ion concentration; iatrogenic disease; nucleotide; mammary neoplasms, experimental; cancer transplantation; phosphorus 31; computer analysis; radiation tolerance; nucleotides; creatine phosphate; phosphocreatine; cancer graft; methylcholanthrene; 3 methylcholanthrene; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.
Journal Title: Radiation Research
Volume: 121
Issue: 3
ISSN: 0033-7587
Publisher: Radiation Research Society  
Date Published: 1990-03-01
Start Page: 312
End Page: 319
Language: English
DOI: 10.2307/3577782
PUBMED: 2315448
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025194382&doi=10.2307%2f3577782&partnerID=40&md5=1c440f016ae9d380476f69dfa8561329
Notes: Article -- Export Date: 27 January 2020 -- Source: Scopus
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MSK Authors
  1. Alice B Kornblith
    46 Kornblith
  2. Jason A Koutcher
    278 Koutcher
  3. Alan A. Alfieri
    35 Alfieri
  4. Jae Ho Kim
    25 Kim
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