Anticipatory immune suppression and nausea in women receiving cyclic chemotherapy for ovarian cancer Journal Article

  


Authors: Bovbjerg, D. H.; Redd, W. H.; Maier, L. A.; Holland, J. C.; Lesko, L. M.; Niedzwiecki, D.; Rubin, S. C.; Hakes, T. B.
Article Title: Anticipatory immune suppression and nausea in women receiving cyclic chemotherapy for ovarian cancer
Abstract: Nausea and immune function were assessed in 20 cancer patients in the hospital prior to chemotherapy and compared with assessments conducted at home. Proliferative responses to T-cell mitogens were lower for cells isolated from hospital blood samples than for home samples obtained several days earlier. Patients also experienced increased nausea in the hospital. Hierarchical multiple regression analyses indicated that decreased immune function in the hospital was not related to increased anxiety. The observed anticipatory immune suppression is consistent with the hypothesis that chemotherapy patients may develop conditioned immune suppression as well as conditioned nausea after repeated pairings of hospital stimuli with the emetic and immunosuppressive effects of chemotherapy.
Keywords: adult; clinical article; aged; cisplatin; doxorubicin; chemotherapy; ovarian neoplasms; ovary cancer; nausea; antineoplastic combined chemotherapy protocols; cyclophosphamide; psychological aspect; lymphocyte activation; immune tolerance; anxiety; leukocyte count; immune deficiency; middle age; human; female; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; vomiting, anticipatory
Journal Title: Journal of Consulting and Clinical Psychology
Volume: 58
Issue: 2
ISSN: 0022-006X
Publisher: American Psychological Association  
Date Published: 1990-04-01
Start Page: 153
End Page: 157
Language: English
DOI: 10.1037/0022-006x.58.2.153
PUBMED: 2335631
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025026091&doi=10.1037%2f0022-006X.58.2.153&partnerID=40&md5=d1d4724485d338d0312d5c8d7ce5ec12
Notes: Article -- Export Date: 27 January 2020 -- Source: Scopus
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MSK Authors
  1. Jimmie C B Holland
    379 Holland
  2. Thomas B Hakes
    115 Hakes
  3. Stephen C. Rubin
    112 Rubin
  4. William H. Redd
    48 Redd
  5. Lynna M. Lesko
    40 Lesko
  6. Donna Niedzwiecki
    61 Niedzwiecki
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