Effects of hematopoietic growth factors following myeloablation in a primate model Journal Article

  


Authors: O'Reilly, R. J.; Gillio, A.; Gasparetto, C.
Article Title: Effects of hematopoietic growth factors following myeloablation in a primate model
Abstract: The complex effects of hematopoietic growth factors (granulocyte and granulocyte‐macrophage colony‐stimulating factors and interleukin 3 and interleukin 1β) following myeloablation in juvenile male cynomolgus monkeys was studied. Since the effects of a given cytokine in vivo do not necessarily reflect the in vitro situation, and since cytokines are frequently species specific, extrapolation from rodent models to man may be fraught with inaccuracies. A primate model, therefore, was developed which has provided useful preclinical information on hematopoietic responses, dose response relationships and toxicities associated with administration of recombinant hematopoietic growth factors. This information has direct application to human trials. Copyright © 1990 AlphaMed Press
Keywords: fluorouracil; conference paper; comparative study; animal; models, biological; granulocyte macrophage colony stimulating factor; interleukin 1beta; animal model; cyclophosphamide; animalia; recombinant proteins; hematopoiesis; blood cell count; alkylating agents; monkey; granulocyte colony stimulating factor; granulocyte colony-stimulating factor; colony-stimulating factors; intravenous drug administration; interleukin-1; growth substances; macaca fascicularis; granulocyte-macrophage colony-stimulating factor; primates; interleukin 3; interleukin-3; primate model; myeloablation; male; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; hematopoietic growth factors; bone marrow ablation
Journal Title: International Journal of Cell Cloning
Volume: 8
Issue: Suppl. 1
ISSN: 0737-1454
Publisher: AlphaMed Press  
Date Published: 1990-01-01
Start Page: 262
End Page: 267; discussion 267-9
Language: English
DOI: 10.1002/stem.5530080724
PUBMED: 1691247
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025161457&doi=10.1002%2fstem.5530080724&partnerID=40&md5=06ec577d08f688887e6348f8b5f6681b
Notes: Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Richard O'Reilly
    747 O'Reilly
  2. Alfred P. Gillio
    89 Gillio
Related MSK Work