Patterns of cervical node metastases from squamous carcinoma of the oropharynx and hypopharynx Journal Article


Authors: Candela, F. C.; Kothari, K.; Shah, J. P.
Article Title: Patterns of cervical node metastases from squamous carcinoma of the oropharynx and hypopharynx
Abstract: A retrospective review of 333 previously untreated patients from 1965 to 1986, with primary squamous cell carcinoma of the oropharynx or hypopharynx, was undertaken to ascertain the prevalence of neck node metastases by neck level. The 333 patients underwent 344 classical radical neck dissections. Patients were grouped by clinical neck status at the time of neck dissection: elective dissection in the NO neck (N = 71), and immediate therapeutic dissection in the N+ neck (N = 259). Detailed analysis was performed for each group based on the specific primary site. This revealed a predominance of neck node metastases in levels II, III, and IV for both oropharyngeal and hypopharyngeal primaries. Isolated “skip” metastases outside of levels II, III, or IV occurred in only 1 patient (0.3%). Otherwise, level I or V involvement was always associated with nodal metastases at other levels (ie, N2 disease). These data support the trend toward selective limited neck dissection (anterior modified) in NO patients. Furthermore, they provide the foundation for planning of future prospective trials to assess the efficacy of modifications in the extent of neck dissection for carcinomas of the oropharynx or hypopharynx. Copyright © 1990 Wiley Periodicals, Inc., A Wiley Company
Keywords: adolescent; adult; child; school child; aged; aged, 80 and over; retrospective studies; major clinical study; neck dissection; squamous cell carcinoma; carcinoma, squamous cell; comparative study; cancer staging; methodology; lymphatic metastasis; neoplasm staging; neck; cervical lymph node; oropharynx carcinoma; oropharyngeal neoplasms; hypopharynx cancer; hypopharyngeal neoplasms; middle age; neck metastasis; pharyngeal neoplasms; human; male; female; priority journal; article
Journal Title: Head & Neck
Volume: 12
Issue: 3
ISSN: 1043-3074
Publisher: John Wiley & Sons, Inc.  
Date Published: 1990-05-01
Start Page: 197
End Page: 203
Language: English
DOI: 10.1002/hed.2880120302
PUBMED: 2358329
PROVIDER: scopus
DOI/URL:
Notes: Source: Scopus
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  1. Jatin P Shah
    721 Shah