Inactivity of terbinafine in a rat model of pulmonary aspergillosis Journal Article
| Authors: | Schmitt, H. J.; Andrade, J.; Edwards, F.; Niki, Y.; Bernard, E.; Armstrong, D. |
| Article Title: | Inactivity of terbinafine in a rat model of pulmonary aspergillosis |
| Abstract: | In a model of bronchopulmonary aspergillosis terbinafine did not improve survival of experimental animals in doses up to 80 mg/kg/day despite adequate lung concentrations. Pretreatment and aerosolization of the compound were also ineffective. Terbinafine was markedly less active in vitro when serum was used instead of Yeast-Nitrogen-Glucose-broth. It is concluded that a lack of bioavailability in the presence of serum may explain the lack of activity of terbinafine in experimental aspergillosis. © 1990 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH. |
| Keywords: | survival; controlled study; drug efficacy; nonhuman; animal; animal tissue; bioassay; rat; lung; drug tissue level; rats; disease models, animal; antifungal agents; aspergillus fumigatus; aspergillosis; lung aspergillosis; bioavailability; biological availability; experimental infection; antimicrobial activity; minimum inhibitory concentration; naphthalenes; intraperitoneal drug administration; amphotericin b; rats, inbred strains; aerosols; lung diseases, fungal; lung weight; aspergillus flavus; aspergillus niger; male; priority journal; article; inhalational drug administration; terbinafine |
| Journal Title: | European Journal of Clinical Microbiology and Infectious Diseases |
| Volume: | 9 |
| Issue: | 11 |
| ISSN: | 0934-9723 |
| Publisher: | Springer |
| Date Published: | 1990-11-01 |
| Start Page: | 832 |
| End Page: | 835 |
| Language: | English |
| DOI: | 10.1007/bf01967386 |
| PUBMED: | 2128278 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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