The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus Journal Article

  

Authors:	Huang, E.; Nocka, K.; Beier, D. R.; Chu, T. Y.; Buck, J.; Lahm, H. W.; Wellner, D.; Leder, P.; Besmer, P.
Article Title:	The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus
Abstract:	Mutations at the steel locus (SI) of the mouse affect the same cellular targets as mutations at the white spotting locus (W), which is allelic with the c-kit proto-oncogene. We show that KL, a hematopoietic growth factor obtained from conditioned medium of BALB c 3T3 flbroblasts that stimulates the proliferation of mast cells and early erythroid progenitors, specifically binds to the c-kit receptor. The predicted amino acid sequence of isolated KL-specific cDNA clones suggests that KL is synthesized as an integral transmembrane protein. Linkage analysis maps the KL gene to the SI locus on mouse chromosome 10, and KL sequences are deleted in the genome of the SI mouse. These results indicate that the SI locus encodes the ligand of the c-kit receptor, KL. © 1990.
Keywords:	mutation; proto-oncogene proteins; nonhuman; animal cell; animal; mice; cell line; gene locus; gene product; transcription, genetic; mice, inbred balb c; animalia; mice, inbred strains; cloning, molecular; dna; amino acid sequence; molecular sequence data; ligands; base sequence; hematopoietic stem cell; receptor; growth factor; molecular weight; protein kinase; chromosome mapping; protein-tyrosine kinase; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; hematopoietic cell growth factors; genes, structural; proto-oncogene protein c-kit
Journal Title:	Cell
Volume:	63
Issue:	1
ISSN:	0092-8674
Publisher:	Cell Press
Date Published:	1990-10-05
Start Page:	225
End Page:	233
Language:	English
DOI:	10.1016/0092-8674(90)90303-v
PUBMED:	1698557
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025077796&doi=10.1016%2f0092-8674%2890%2990303-V&partnerID=40&md5=1400f1b7a1e0a693fad2710d12de84bc
Notes:	Article -- Export Date: 27 January 2020 -- Source: Scopus

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