Toxoplasma gondii serology in HIV-infected patients: The development of central nervous system toxoplasmosis in AIDS Journal Article

  


Authors: Grant, I. H.; Gold, J. W. M.; Rosenblum, M.; Niedzwiecki, D.; Armstrong, D.
Article Title: Toxoplasma gondii serology in HIV-infected patients: The development of central nervous system toxoplasmosis in AIDS
Abstract: Central nervous system (CNS) toxoplasmosis is an important infectious complication of AIDS which requires prolonged treatment. Most cases occur in patients with serologic evidence of prior exposure and therefore appear to result from reactivation of a previously acquired infection. Antibody to Toxoplasma gondii was found in 130 out of 411 patients with AIDS (32%). Of these, CNS toxoplasmosis developed in 31 (24%). By survival analysis, the estimated probabilility of ever developing CNS infection in antibody-positive individuals was 28%, occurring in 26% of patients within 2 years of the onset of AIDS. All patients with HIV infection should be tested for antibody to T.gondii and monitored for any neurologic change. Methods of prophylaxis for CNS toxoplasmosis in these high-risk patients need to be developed.
Keywords: adult; major clinical study; nonhuman; human immunodeficiency virus infection; animal; prevalence; central nervous system; risk assessment; homosexuality; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; protozoon; toxoplasmosis; central nervous system diseases; toxoplasma gondii; toxoplasma; serologic tests; human; male; priority journal; article; support, u.s. gov't, p.h.s.; antibodies, protozoan; risk of toxoplasmosis in aids; toxoplasma serology
Journal Title: AIDS
Volume: 4
Issue: 6
ISSN: 0269-9370
Publisher: Lippincott Williams & Wilkins  
Date Published: 1990-06-01
Start Page: 519
End Page: 521
Language: English
PUBMED: 2386617
PROVIDER: scopus
DOI: 10.1097/00002030-199006000-00004
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025323614&partnerID=40&md5=7da199cebda53db6319104535789477b
Notes: Article -- Source: Scopus
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MSK Authors
  1. Marc Rosenblum
    424 Rosenblum
  2. Donald Armstrong
    240 Armstrong
  3. Donna Niedzwiecki
    61 Niedzwiecki
  4. Jonathan W. M. Gold
    73 Gold
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