Sun exposure, vitamin D receptor polymorphisms FokI and BsmI and risk of multiple primary melanoma Journal Article
| Authors: | Mandelcorn-Monson, R.; Marrett, L.; Kricker, A.; Armstrong, B. K.; Orlow, I.; Goumas, C.; Paine, S.; Rosso, S.; Thomas, N.; Millikan, R. C.; Pole, J. D.; Cotignola, J.; Rosen, C.; Kanetsky, P. A.; Lee-Taylor, J.; Begg, C. B.; Berwick, M. |
| Article Title: | Sun exposure, vitamin D receptor polymorphisms FokI and BsmI and risk of multiple primary melanoma |
| Abstract: | Background: Sunlight exposure increases risk of melanoma. Sunlight also potentiates cutaneous synthesis of vitamin D, which can inhibit melanoma cell growth and promote apoptosis. Vitamin D effects are mediated through the vitamin D receptor (VDR). We hypothesized that genetic variation in VDR affects the relationship of sun exposure to risk of a further melanoma in people who have already had one. Methods: We investigated the interaction between VDR polymorphisms and sun exposure in a population-based multinational study comparing 1138 patients with a multiple (second or subsequent) primary melanoma (cases) to 2151 patients with a first primary melanoma (controls); essentially a case-control study of melanoma in a population of melanoma survivors. Sun exposure was assessed using a questionnaire and interview, and was shown to be associated with multiple primary melanoma. VDR was genotyped at the FokI and BsmI loci and the main effects of variants at these loci and their interactions with sun exposure were analyzed. Results: Only the BsmI variant was associated with multiple primary melanoma (OR = 1.27, 95% CI 0.99-1.62 for the homozygous variant genotype). Joint effects analyses showed highest ORs in the high exposure, homozygous variant BsmI genotype category for each sun exposure variable. Stratified analyses showed somewhat higher ORs for the homozygous BsmI variant genotype in people with high sun exposure than with low sun exposure. P values for interaction, however, were high. Conclusion: These results suggest that risk of multiple primary melanoma is increased in people who have the BsmI variant of VDR. © 2011 Elsevier Ltd. |
| Keywords: | adult; controlled study; aged; middle aged; unclassified drug; major clinical study; case-control studies; polymorphism, single nucleotide; cancer risk; genetic predisposition to disease; melanoma; sun exposure; skin neoplasms; protein; gene locus; genetic variability; genotype; risk factors; cancer survivor; risk assessment; questionnaire; reverse transcriptase polymerase chain reaction; homozygote; interview; genetic risk; vitamin d receptor; multiple cancer; receptor gene; sunlight; dna polymorphism; population based case control study; genotype environment interaction; bsmi; foki; protein bsmi; protein foki; receptors, calcitriol |
| Journal Title: | Cancer Epidemiology |
| Volume: | 35 |
| Issue: | 6 |
| ISSN: | 1877-7821 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2011-12-01 |
| Start Page: | e105 |
| End Page: | e110 |
| Language: | English |
| DOI: | 10.1016/j.canep.2011.03.003 |
| PROVIDER: | scopus |
| PMCID: | PMC3182291 |
| PUBMED: | 21612999 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 9 December 2011" - "Source: Scopus" |
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