The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival Journal Article

Authors: Orlow, I.; Shi, Y.; Kanetsky, P. A.; Thomas, N. E.; Luo, L.; Corrales-Guerrero, S.; Cust, A. E.; Sacchetto, L.; Zanetti, R.; Rosso, S.; Armstrong, B. K.; Dwyer, T.; Venn, A.; Gallagher, R. P.; Gruber, S. B.; Marrett, L. D.; Anton-Culver, H.; Busam, K.; Begg, C. B.; Berwick, M.; for the GEM Study Group
Contributors: Roy, P.; Patel, H.; Yoo, S.; Reiner, A.
Article Title: The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival
Abstract: Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3′-end haplotype were significant (p <.05). These SNPs, and a haplotype, had a statistically significant association with survival among subjects exposed to high UVB in multivariable regression models and exerted their effect in the opposite direction among those with low UVB. SNPs rs1544410/BsmI and rs731236/TaqI remained significant after adjustment for multiple testing. These results suggest that the association between VDR and melanoma-specific survival is modified by sun exposure around diagnosis, and require validation in an independent study. Whether the observed effects are dependent or independent of vitamin D activation remains to be determined. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Keywords: survival; cancer survival; survival rate; major clinical study; single nucleotide polymorphism; outcome assessment; follow up; disease association; melanoma; sun exposure; clinical assessment; genetic association; protein interaction; haplotype; interaction; incidental finding; ultraviolet b radiation; vitamin d receptor; genetic polymorphism; polymorphism; uvb; exposure; snp; time to treatment; human; male; female; article
Journal Title: Pigment Cell & Melanoma Research
Volume: 31
Issue: 2
ISSN: 1755-1471
Publisher: Wiley Blackwell  
Date Published: 2018-03-01
Start Page: 287
End Page: 296
Language: English
DOI: 10.1111/pcmr.12653
PROVIDER: scopus
PMCID: PMC5809306
PUBMED: 28990310
Notes: Article -- Export Date: 1 March 2018 -- Source: Scopus
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MSK Authors
  1. Anne S Reiner
    120 Reiner
  2. Colin B Begg
    234 Begg
  3. Irene Orlow
    191 Orlow
  4. Klaus J Busam
    535 Busam
  5. Pampa Roy
    32 Roy
  6. Himali S Patel
    8 Patel
  7. Sarah Min Kyung Yoo
    9 Yoo