Does interleukin-1 save B-cells from paralysis? Studies with pre-B cells and antigen-reactive B-cells Journal Article
| Authors: | Dennig, D.; Mecheri, S.; Dannecker, G.; Kimura, S.; Hoffmann, M. |
| Article Title: | Does interleukin-1 save B-cells from paralysis? Studies with pre-B cells and antigen-reactive B-cells |
| Abstract: | The role of the second messenger cAMP in the differentiation of the pre-B cell line 70Z/3 and in the initial phase of the immune response of B cells, IgM antibody production is examined. Our data indicate that in these B cells, the elevation of intracellular cAMP levels can have two fundamentally different effects: it may dedifferentiate B cells and cause their disintegration (catabolic pathway) or it may induce their differentiation and maturation (anabolic pathway). The switch that determines which pathway B cells enter is set by interleukin-1. Our experiments indicate that intracellular cAMP levels rise in B cells when they interact with helper T cells in a cognate interaction. Given the dual effect that cAMP may have on the fate of B cells, activation or destruction, our data may be taken to suggest that helper T cells may direct B cells into catabolic or anabolic responses, depending on the availability of a costimulatory signal mediated by interleukin-1. |
| Keywords: | immunoglobulin; transgenic mice; erythrocytes; expression; induction; t-cells; immunological-tolerance; invitro; bacterial lipopolysaccharide; unresponsiveness; lymphocytes-b |
| Journal Title: | Lymphokine and Cytokine Research |
| Volume: | 10 |
| Issue: | 1-2 |
| ISSN: | 0277-6766 |
| Publisher: | Mary Ann Liebert, Inc |
| Date Published: | 1991-04-01 |
| Start Page: | 27 |
| End Page: | 34 |
| Language: | English |
| ACCESSION: | WOS:A1991FL93200005 |
| PROVIDER: | wos |
| PUBMED: | 1651768 |
| Notes: | Source: Wos |
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