Role of chemotherapy and biomolecular therapy in the treatment of uterine sarcomas Journal Article
| Author: | Hensley, M. L. |
| Article Title: | Role of chemotherapy and biomolecular therapy in the treatment of uterine sarcomas |
| Abstract: | Uterine sarcomas are rare, high-risk malignancies. Expert histologic review is important for accurate diagnosis. For high-grade leiomyosarcomas, the risk of recurrence is high after complete resection of uterus-limited disease; however, no adjuvant therapy has been proven to improve survival. Chemotherapy regimens with efficacy in treating advanced uterine leiomyosarcoma include gemcitabine-docetaxel, doxorubicin and ifosfamide. Uterine carcinosarcomas also carry a high risk of recurrence. Adjuvant chemotherapy is a standard approach for completely resected and metastatic carcinosarcoma. Active agents include carboplatin, cisplatin, ifosfamide and paclitaxel. © 2011 Elsevier Ltd. All rights reserved. |
| Keywords: | treatment outcome; treatment response; survival rate; overall survival; thalidomide; fatigue; neutropenia; review; cancer recurrence; sorafenib; bevacizumab; cisplatin; doxorubicin; sunitinib; advanced cancer; cancer combination chemotherapy; drug efficacy; skin toxicity; gemcitabine; paclitaxel; cancer adjuvant therapy; cancer radiotherapy; chemotherapy; temozolomide; topotecan; drug megadose; imatinib; carboplatin; dacarbazine; unindexed drug; multiple cycle treatment; etoposide; bleeding; cyclophosphamide; continuous infusion; ifosfamide; docetaxel; exemestane; protein tyrosine kinase inhibitor; pneumothorax; cardiotoxicity; mitoxantrone; pazopanib; soft tissue sarcoma; sepsis; letrozole; intestine perforation; trabectedin; leiomyosarcoma; estrogen receptor; progesterone receptor; anastrozole; alopecia; wound dehiscence; uterine leiomyosarcoma; uterus sarcoma; liposarcoma; carcinosarcoma; randomized controlled trial (topic); megestrol; trimetrexate; high undifferentiated sarcoma; piperazinedione |
| Journal Title: | Best Practice and Research: Clinical Obstetrics and Gynaecology |
| Volume: | 25 |
| Issue: | 6 |
| ISSN: | 1521-6934 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2011-12-01 |
| Start Page: | 773 |
| End Page: | 782 |
| Language: | English |
| DOI: | 10.1016/j.bpobgyn.2011.06.003 |
| PROVIDER: | scopus |
| PUBMED: | 21752717 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 9 December 2011" - "CODEN: BPRCF" - "Source: Scopus" |
