Options for adjuvant therapy for uterine leiomyosarcoma Journal Article


Authors: Friedman, C. F.; Hensley, M. L.
Article Title: Options for adjuvant therapy for uterine leiomyosarcoma
Abstract: Uterine leiomyosarcoma (uLMS) is a rare disease; in the data from the SEER database, 3165 cases of uLMS were diagnosed between January 2000 and December 2012. While a majority of patients (60%) are diagnosed with early stage disease, recurrence rates are high. Five-year disease-specific survival is 76% for patients with FIGO stage I and 60% for patients with FIGO stage II disease. Adjuvant treatments, including radiation therapy, chemotherapy, and combined modality approaches, have been explored with the goal of demonstrating improved survival. However, heterogeneous patient populations, small sample sizes, and lack of no-treatment control arms have limited the interpretation and reliability of the results from these studies. A randomized trial of adjuvant pelvic radiation compared to no additional treatment showed that adjuvant radiation did not improve recurrence or survival outcomes for early-stage uterine LMS. To date, no prospective, randomized trial has been completed comparing adjuvant chemotherapy to observation. A recent well-designed retrospective study showed that women treated with adjuvant gemcitabine-docetaxel had no improvement in progression-free or overall survival compared to women who received no additional treatment. Thus, current data support our recommendation against adjuvant radiation or chemotherapy treatment for patients with non-morcellated, completely resected, and uterine-confined leiomyosarcoma. We recommend that these patients be observed with periodic surveillance imaging and physical examinations. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
Keywords: cancer survival; treatment response; cancer surgery; overall survival; review; cancer recurrence; doxorubicin; multimodality cancer therapy; gemcitabine; adjuvant therapy; cancer adjuvant therapy; chemotherapy; cancer staging; outcome assessment; metastasis; progression free survival; diagnostic imaging; ifosfamide; docetaxel; cancer hormone therapy; diagnostic value; cancer specific survival; soft tissue sarcoma; radiation therapy; physical examination; adjuvant radiotherapy; uterine leiomyosarcoma; uterus sarcoma; randomized controlled trial (topic); comparative effectiveness; clinical outcome; metastasis resection; olaratumab; morcellation; human; early cancer diagnosis
Journal Title: Current Treatment Options in Oncology
Volume: 19
Issue: 2
ISSN: 1527-2729
Publisher: Springer  
Date Published: 2018-02-01
Start Page: 7
Language: English
DOI: 10.1007/s11864-018-0526-0
PROVIDER: scopus
PUBMED: 29417238
DOI/URL:
Notes: Review -- Export Date: 1 March 2018 -- Source: Scopus
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  1. Martee L Hensley
    257 Hensley