Melanomas of childhood Journal Article
| Author: | Spitz, S. |
| Article Title: | Melanomas of childhood |
| Abstract: | Of 13 cases of juvenile melanoma in this series, only one (7.7 percent) has had a clinically malignant and fatal course despite the similarity of the juvenile lesions to the malignant melanoma of adults. Juvenile melanoma may be distinguished histologically from adult melanoma in about one half the cases by the presence of giant cells in the former, which seldom occur in the latter. There is a precipitous rise in the capacity of melanomas to metastasize after puberty despite the histologic similarity to the usually nonmetastasizing juvenile melanoma. The possible influence of sex-linked hormonal activation of the growth capacity of melanomas at the age of puberty seems a logical conclusion. Accordingly, since metastases from juvenile melanomas occur only rarely, conservative surgery, rather than the radical surgery usually indicated for adult melanomas, seems justified. |
| Keywords: | child; clinical article; review; melanoma; skin neoplasms; childhood cancer; history; skin tumor; history of medicine; human; male; female; priority journal; article; history of medicine, 20th cent. |
| Journal Title: | CA - A Cancer Journal for Clinicians |
| Volume: | 41 |
| Issue: | 1 |
| ISSN: | 0007-9235 |
| Publisher: | Wiley-Blackwell |
| Date Published: | 1991-01-01 |
| Start Page: | 40 |
| End Page: | 51 |
| Language: | English |
| DOI: | 10.3322/canjclin.41.1.40 |
| PUBMED: | 1898635 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Reprint - Originally appeared in Am J Pathol 24:591-609, 1948 -- Export Date: 27 September 2019 -- Source: Scopus |
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