Unconjugated monoclonal antibodies as anticancer agents Journal Article

  


Authors: Chapman, P. B.; Scheinberg, D. A.; DiMaggio, J. J.; Houghton, A. N.
Article Title: Unconjugated monoclonal antibodies as anticancer agents
Abstract: Induction of a specific inflammatory response against human cancer has long been a goal of tumor immunologists. Monoclonal antibodies (moAbs) specific for antigens expressed by cancer cells can be used to direct the inflammatory response against tumors. Several different strategies are currently being pursued and are reviewed in this article. Using molecular biology techniques, newer approaches will entail the ''humanization'' of mouse moAbs as well as the construction of antibody subunits with the desired specificities.
Keywords: controlled study; review; mouse; animal experiment; inflammation; monoclonal antibody; immunosuppressive agent; cancer immunology; human
Journal Title: Immunology and Allergy Clinics of North America
Volume: 11
Issue: 2
ISSN: 0889-8561
Publisher: Elsevier Inc.  
Date Published: 1991-05-01
Start Page: 257
End Page: 275
Language: English
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025908128&partnerID=40&md5=aeb76b857425306e01d8abe7b56011b3
Notes: Review -- Export Date: 27 September 2019 -- Source: Scopus