Phenotypic and functional stages in the intrathymic development of αβ T cells Journal Article

  


Author: Nikolić-Žugić, J.
Article Title: Phenotypic and functional stages in the intrathymic development of αβ T cells
Abstract: The thymus is the main site o f T-cell maturation. On arrival in the thymus, CD8-CD4- double-negative (DN) T-cell precursors undergo extensive gene rearrangement, phenotypic alteration and biochemical modi fication to yield the population of thymocytes that undergoes intrathymic selection. The selected mature thymocytes then go on to seed the periphery. In this article Janko Nikolić-Žugić discusses the labyrinthine development that constitutes αβ T-cell maturation and selection. © 1991.
Keywords: review; nonhuman; t lymphocyte; biological markers; mouse; phenotype; animal; mice; cell division; models, biological; cell maturation; cell differentiation; selection (genetics); gene expression regulation; t lymphocyte receptor; membrane antigen; thymus; receptors, antigen, t-cell; thymus gland; hematopoietic stem cells; cell movement; t-lymphocyte subsets; antigens, cd; ontogeny; antigens, differentiation, t-lymphocyte; receptors, interleukin-2; human; priority journal; support, u.s. gov't, p.h.s.
Journal Title: Immunology Today
Volume: 12
Issue: 2
ISSN: 0167-5699
Publisher: Elsevier Science, Inc.  
Date Published: 1991-02-01
Start Page: 65
End Page: 70
Language: English
DOI: 10.1016/0167-5699(91)90160-u
PUBMED: 2059306
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026067467&doi=10.1016%2f0167-5699%2891%2990160-U&partnerID=40&md5=b216892bc347390bf5c33620f8e0e56d
Notes: Review -- Export Date: 27 September 2019 -- Source: Scopus
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MSK Authors
  1. Janko Nikolich-Zugich
    79 Nikolich-Zugich
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