Correlation of IL-6 secretion and hyponatremia with the use of CD19+ chimeric antigen receptor T-cells Journal Article
| Authors: | Dixon, B. N.; Daley, R. J.; Buie, L. W.; Hsu, M.; Park, J. H.; Brentjens, R. J.; Purdon, T. J.; Latcha, S. |
| Article Title: | Correlation of IL-6 secretion and hyponatremia with the use of CD19+ chimeric antigen receptor T-cells |
| Abstract: | Background: Various studies have demonstrated that interleukin-6 (IL-6) activates the central magnocellular arginine vasopressin (AVP)-secreting neurons in the brain to produce non-osmotic, non-volumemediated increases in AVP. The most common toxicity of CD19+ chimeric antigen receptor (CAR) T-cells is cytokine release syndrome, which is related to increased levels of IL-6. This study will evaluate the correlation of IL-6 levels with hyponatremia in patients receiving CD19+ CAR T-cells. Materials and methods: This is a single-center retrospective analysis of adult patients who received CD19+ CAR T-cells for the treatment of relapsed/refractory acute lymphoblastic leukemia (ALL). Results: Hyponatremia, defined as a serum sodium (Na) <= 135 mEq/L, occurred in 31 (61%) patients. A change in Na > 7 mEq occurred in 32 (63%) patients, and the median lowest Na was 133 mEq/L (interquartilc range (IQR): 131 - 136)). There was an inverse linear relationship between IL-6 levels and lowest Na (p = 0.001). Overall, per 10-fold increase in IL-6, Na decreased by an average of 2.68 mEq/L. Conclusion: Hyponatremia is common in patients who received CD19+ CAR T-cells. There is an inverse linear relationship between IL-6 levels and nadir Na (p = 0.001). Further studies will be needed to confirm a causative relationship between IL-6 levels and hyponatremia following CD19+ CAR T-cell infusion. |
| Keywords: | hyponatremia; interleukin-6; vasopressin; activation; il-6; pituitary-adrenal axis; cd19+car t-cells |
| Journal Title: | Clinical Nephrology |
| Volume: | 93 |
| Issue: | 1 |
| ISSN: | 0301-0430 |
| Publisher: | Dustri-Verlag Dr. Karl Feistle |
| Date Published: | 2020-01-01 |
| Start Page: | 42 |
| End Page: | 46 |
| Language: | English |
| ACCESSION: | WOS:000500921800006 |
| DOI: | 10.5414/cn109872 |
| PROVIDER: | wos |
| PUBMED: | 31670650 |
| PMCID: | PMC9904099 |
| Notes: | Article -- Source: Wos |
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