Gastrointestinal cancer educational case series: Management of metastatic adenocarcinoma of unknown primary origin in a Ph+ ALL survivor Journal Article
| Authors: | Ang, C.; O'Reilly, E. M.; Abou-Alfa, G. K.; Shamseddine, A.; Skouri, H.; Tawil, A.; Eloubeidi, M. A.; Lowery, M.; Kharfan-Dabaja, M.; Kaprealian, T.; Temraz, S.; Sibai, H.; Farran, H.; Shah, M. A. |
| Article Title: | Gastrointestinal cancer educational case series: Management of metastatic adenocarcinoma of unknown primary origin in a Ph+ ALL survivor |
| Abstract: | Introduction: Secondary malignancies and chronic endorgan sequelae are significant and steadily rising consequences of cancer therapy. The workup and management of a carcinoma of unknown primary must consider the patient's clinical presentation, radiologic and pathologic findings, and comorbidities. Case Report: We present the case of a 50-year-old female survivor of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) with significant treatmentrelated end-organ sequelae who developed a metastatic adenocarcinoma of unknown primary 15 years following curative therapy for her ALL. The complex management issues related to the investigations and choice of therapy for this patient are reviewed. Discussion: This case discusses key issues related to the workup and management of a carcinoma of unknown primary. In addition, it illustrates the importance of taking patient comorbidities into consideration and tailoring investigations and therapy accordingly. © Springer Science+Business Media, LLC 2010. |
| Keywords: | immunohistochemistry; adult; human tissue; treatment outcome; middle aged; prednisone; case report; ascites; diarrhea; drug dose reduction; hypertension; liver cirrhosis; monotherapy; gemcitabine; cytarabine; methotrexate; nuclear magnetic resonance imaging; positron emission tomography; paraaortic lymph node; adenocarcinoma; protein blood level; computer assisted tomography; drug eruption; sensory neuropathy; etoposide; thrombocytopenia; antineoplastic combined chemotherapy protocols; ca 19-9 antigen; epidermal growth factor receptor; genotype; smoking; creatinine; cyclophosphamide; vincristine; allogenic bone marrow transplantation; creatinine blood level; kidney failure; urea nitrogen blood level; wild type; acute lymphoblastic leukemia; survivors; depression; liver metastasis; whole body radiation; colonoscopy; family history; hepatomegaly; mitoxantrone; hypermetabolism; asparaginase; anxiety disorder; precursor cell lymphoblastic leukemia-lymphoma; contrast medium; pleura effusion; metabolic syndrome x; thorax radiography; bile duct carcinoma; cancer of unknown primary site; ca 125 antigen; cytokeratin 7; aspiration biopsy; k ras protein; lung biopsy; defibrillator; congestive heart failure; disease exacerbation; fluorodeoxyglucose; hearing loss; nitrogen; drinking behavior; endoscopic echography; multiple organ failure; leukemia remission; kidney cyst; neoplasms, unknown primary; recurrent laryngeal nerve; abdominal discomfort; vimentin; lung nodule; artificial heart pacemaker; common acute lymphoblastic leukemia antigen; urea; secondary malignancies; heart ejection fraction; congestive cardiomyopathy; cytokeratin 10; philadelphia chromosome positive cell; liver nodule; cancer therapy-induced cardiotoxicity; carcinoma of unknown primary investigations; carcinoma of unknown primary management |
| Journal Title: | Journal of Gastrointestinal Cancer |
| Volume: | 42 |
| Issue: | 3 |
| ISSN: | 1941-6628 |
| Publisher: | Springer |
| Date Published: | 2011-09-01 |
| Start Page: | 165 |
| End Page: | 170 |
| Language: | English |
| DOI: | 10.1007/s12029-010-9233-1 |
| PROVIDER: | scopus |
| PUBMED: | 21128012 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 9 December 2011" - "Source: Scopus" |
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