Biology and therapeutic advances for pediatric osteosarcoma Journal Article
| Authors: | Marina, N.; Gebhardt, M.; Teot, L.; Gorlick, R. |
| Article Title: | Biology and therapeutic advances for pediatric osteosarcoma |
| Abstract: | Osteosarcoma is the most common malignant bone tumor in children and adolescents. Survival for these patients was poor with the use of surgery and/or radiotherapy. The introduction of multi-agent chemotherapy dramatically improved the outcome for these patients and the majority of modern series report 3-year disease-free survival of 60%-70%. This paper describes current strategies for treating patients with osteosarcoma as well as review of the clinical features, radiologic and diagnostic work-up, and pathology. The authors review the state of the art management for patients with osteosarcoma in North America and Europe including the use of limb-salvage procedures and reconstruction as well as discuss the etiologic and biologic factors associated with tumor development. Therapy-related sequelae and future directions in the biology and therapy for these patients are also discussed. |
| Keywords: | osteosarcoma; cancer survival; treatment outcome; bone neoplasms; bone graft; cancer surgery; endoprosthesis; limb salvage; clinical feature; clinical trial; histopathology; pathogenesis; review; cancer recurrence; cisplatin; doxorubicin; cancer combination chemotherapy; dose response; drug efficacy; nonhuman; drug targeting; alpha interferon; cancer adjuvant therapy; cancer radiotherapy; postoperative care; methotrexate; drug megadose; follow up; cancer incidence; neoplasm staging; treatment indication; dna damage; imatinib; computer assisted tomography; gene amplification; biology; etoposide; differential diagnosis; granulocyte macrophage colony stimulating factor; cyclophosphamide; patient monitoring; continuous infusion; diagnostic imaging; protein p53; ifosfamide; childhood cancer; infertility; hypomagnesemia; postoperative complication; tumor suppressor gene; lung metastasis; cancer regression; gamma interferon; cardiotoxicity; needle biopsy; dactinomycin; amputation; drug infusion; bleomycin; thymidine kinase; cancer epidemiology; adenovirus vector; trastuzumab; anthracycline; retinoblastoma protein; radiodiagnosis; bone remodeling; therapy; interleukin 12; hearing loss; cardiomyopathy; pediatrics; bone radiography; bone allograft; bone biopsy; viral gene therapy; bone growth; pediatric osteosarcoma; n acetylmuramylalanyl dextro isoglutaminylalanyl dipalmitoylphosphatidylethanolamine; samarium; razoxane; osteocalcin; humans; prognosis; human; priority journal; multidisciplinary treatment; therapeutic advances; trimetrexate glucuronate |
| Journal Title: | The Oncologist |
| Volume: | 9 |
| Issue: | 4 |
| ISSN: | 1083-7159 |
| Publisher: | Oxford University Press |
| Date Published: | 2004-07-01 |
| Start Page: | 422 |
| End Page: | 441 |
| Language: | English |
| DOI: | 10.1634/theoncologist.9-4-422 |
| PROVIDER: | scopus |
| PUBMED: | 15266096 |
| DOI/URL: | |
| Notes: | Oncologist -- Cited By (since 1996):228 -- Export Date: 16 June 2014 -- CODEN: OCOLF -- Source: Scopus |
