Membrane boned axin is sufficient for wingless signaling in drosophila embryos Journal Article
| Author: | Tolwinski, N. S. |
| Article Title: | Membrane boned axin is sufficient for wingless signaling in drosophila embryos |
| Abstract: | The Wingless signaling pathway controls various developmental processes in both vertebrates and invertebrates. Here I probe the requirement for nuclear localization of APC2 and Axin in the Wg signal transduction pathway during embryonic development of Drosophila melanogaster. I find that nuclear localization of APC2 appears to be required, but Axin can block signaling when tethered to the membrane. These results support the model where Axin regulates Armadillo localization and activity in the cytoplasm. Copyright © 2009 by the Genetics Society of America. |
| Keywords: | signal transduction; unclassified drug; nonhuman; protein function; protein localization; animal; cytology; metabolism; animals; embryo; embryo development; morphogenesis; vertebrata; prenatal development; cell membrane; adaptor proteins, signal transducing; cytoplasm; drosophila melanogaster; cell nucleus; drosophila proteins; signal transducing adaptor protein; body patterning; apc protein; armadillo domain protein; wnt1 protein; armadillo; drosophila protein; axin; protein apc2; axin protein, drosophila; wg protein, drosophila; invertebrata |
| Journal Title: | Genetics |
| Volume: | 181 |
| Issue: | 3 |
| ISSN: | 0016-6731 |
| Publisher: | Genetics Society of America |
| Date Published: | 2009-03-01 |
| Start Page: | 1169 |
| End Page: | 1173 |
| Language: | English |
| DOI: | 10.1534/genetics.108.098236 |
| PUBMED: | 19124571 |
| PROVIDER: | scopus |
| PMCID: | PMC2651051 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 30 November 2010" - "CODEN: GENTA" - "Source: Scopus" |
