The mouse Fused locus encodes axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation Journal Article

  


Authors: Zeng, L.; Fagotto, F.; Zhang, T.; Hsu, W.; Vasicek, T. J.; Perry Iii, W. L.; Lee, J. J.; Tilghman, S. M.; Gumbiner, B. M.; Costantini, F.
Article Title: The mouse Fused locus encodes axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation
Abstract: Mutations at the mouse Fused locus have pleiotropic developmental effects, including the formation of axial duplications in homozygous embryos. The product of the Fused locus, Axin, displays similarities to RGS (Regulators of G-Protein Signaling) and Dishevelled proteins. Mutant Fused alleles that cause axial duplications disrupt the major mRNA, suggesting that Axin negatively regulates the response to an axis-inducing signal. Injection of Axin mRNA into Xenopus embryos inhibits dorsal axis formation by interfering with signaling through the Wnt pathway. Furthermore, ventral injection of an Axin mRNA lacking the RGS domain induces an ectopic axis, apparently through a dominant-negative mechanism. Thus, Axin is a novel inhibitor of Wnt signaling and regulates an early step in embryonic axis formation in mammals and amphibians.
Keywords: signal transduction; gene mutation; nonhuman; proteins; protein analysis; animal cell; mouse; mammalia; animals; mice; allele; animal tissue; transcription initiation; gene locus; transcription factor; embryo development; animalia; vertebrata; cloning, molecular; embryo, nonmammalian; amino acid sequence; molecular sequence data; sequence homology, amino acid; rna, messenger; sequence alignment; mammal; recombinant proteins; protein biosynthesis; stem cells; gene duplication; dna flanking region; mutagenesis, site-directed; rats; rodentia; mammals; repressor proteins; xenopus; chickens; embryonic induction; humans; priority journal; article; amphibia
Journal Title: Cell
Volume: 90
Issue: 1
ISSN: 0092-8674
Publisher: Cell Press  
Date Published: 1997-07-11
Start Page: 181
End Page: 192
Language: English
DOI: 10.1016/s0092-8674(00)80324-4
PUBMED: 9230313
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031457978&doi=10.1016%2fS0092-8674%2800%2980324-4&partnerID=40&md5=3df199cec4c744d3ba2cfee31e9acbec
Notes: Article -- Export Date: 17 March 2017 -- Source: Scopus
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MSK Authors
  1. Barry M Gumbiner
    75 Gumbiner
  2. Francois Fagotto
    12 Fagotto
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