The evolution of the locoregional therapy of breast cancer Journal Article
| Authors: | Ho, A.; Morrow, M. |
| Article Title: | The evolution of the locoregional therapy of breast cancer |
| Abstract: | Breast-conserving therapy (BCT) and mastectomy have equal survival outcomes. Rates of local recurrence after BCT have declined steadily, largely as a result of the widespread use of systemic therapy. Sentinel node biopsy has replaced axillary dissection for staging the axilla, and in women undergoing BCT with whole-breast irradiation (WBI), axillary dissection is not needed for local control or survival in those with fewer than three involved sentinel nodes. Alternatives to 6 weeks of WBI have been shown to be safe and effective for subsets of breast cancer patients, and the use of preoperative chemotherapy allows BCT in some women who require mastectomy if surgery is the initial step in treatment. The combination of the smaller cancers detected with screening and the routine use of multimodality therapy has resulted in a decrease in the morbidity of local therapy and improved cancer treatment outcomes. © AlphaMed Press. |
| Keywords: | cancer survival; treatment outcome; surgical technique; fluorouracil; placebo; drug efficacy; monotherapy; multimodality cancer therapy; systemic therapy; cancer adjuvant therapy; cancer radiotherapy; combined modality therapy; methotrexate; lymph node metastasis; sentinel node; antineoplastic agent; lymph node dissection; sentinel lymph node biopsy; breast cancer; mastectomy; randomized controlled trials as topic; combination chemotherapy; cyclophosphamide; breast neoplasms; cancer therapy; axillary lymph node; electron therapy; radiation dose fractionation; partial mastectomy; patient safety; brachytherapy; therapy effect; external beam radiotherapy; photon therapy; trastuzumab; computer assisted radiotherapy; breast surgery; mastectomy, segmental; lumpectomy; intraoperative radiotherapy; partial breast irradiation; tamoxifen citrate; locoregional therapy |
| Journal Title: | The Oncologist |
| Volume: | 16 |
| Issue: | 10 |
| ISSN: | 1083-7159 |
| Publisher: | Oxford University Press |
| Date Published: | 2011-01-01 |
| Start Page: | 1367 |
| End Page: | 1379 |
| Language: | English |
| DOI: | 10.1634/theoncologist.2011-0223 |
| PROVIDER: | scopus |
| PUBMED: | 21964004 |
| PMCID: | PMC3228069 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 9 December 2011" - "CODEN: OCOLF" - "Source: Scopus" |
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