Cancer biology as revealed by the research autopsy Journal Article

Authors: Iacobuzio-Donahue, C. A.; Michael, C.; Baez, P.; Kappagantula, R.; Hooper, J. E.; Hollman, T. J.
Article Title: Cancer biology as revealed by the research autopsy
Abstract: A research autopsy is a post-mortem medical procedure performed on a deceased individual with the primary goal of collecting tissue to support basic and translational research. This approach has increasingly been used to investigate the pathophysiological mechanisms of cancer evolution, metastasis and treatment resistance. In this Review, we discuss the rationale for the use of research autopsies in cancer research and provide an evidence-based discussion of the quality of post-mortem tissues compared with other types of biospecimens. We also discuss the advantages of using post-mortem tissues over other types of biospecimens, including the large amounts of tissue that can be obtained and the extent of multiregion sampling that is achievable, which is not otherwise possible in living patients. We highlight how the research autopsy has supported the identification of the clonal origins and modes of spread among metastases, the extent that selective pressures imposed by treatments cause bottlenecks leading to parallel and convergent tumour evolution, and the creation of rare tissue banks and patient-derived model systems. Finally, we comment on the future of the research autopsy as an integral component of precision medicine strategies. © 2019, Springer Nature Limited.
Keywords: review; metastasis; biology; evolution; cancer research; carcinogenesis; cancer resistance; cancer tissue; autopsy; personalized medicine; human; priority journal
Journal Title: Nature Reviews Cancer
Volume: 19
Issue: 12
ISSN: 1474-175X
Publisher: Nature Publishing Group  
Date Published: 2019-12-01
Start Page: 686
End Page: 697
Language: English
DOI: 10.1038/s41568-019-0199-4
PUBMED: 31519982
PROVIDER: scopus
Notes: Review -- Export Date: 2 January 2020 -- Source: Scopus
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