PET/MRI for neuroendocrine tumors: A match made in heaven or just another hype? Journal Article
| Authors: | Pirasteh, A.; Riedl, C.; Mayerhoefer, M. E.; Giancipoli, R. G.; Larson, S. M.; Bodei, L. |
| Article Title: | PET/MRI for neuroendocrine tumors: A match made in heaven or just another hype? |
| Abstract: | Purpose: To evaluate the current literature on technical feasibility and diagnostic value of PET/MRI in management of patients with neuroendocrine tumors (NETs). Methods: A systematic literature search of the PubMed/MEDLINE database identified studies that evaluated the role of simultaneous PET/MRI for the evaluation of neuroendocrine tumors in human subjects. Exclusion criteria included studies lacking simultaneous PET/MRI, absence of other than attenuation-correction MRI pulse sequences, and case reports. No data-pooling or statistical analysis was performed due to the small number of articles and heterogeneity of the methodologies. Results: From the 21 identified articles, five were included, which demonstrated successful technical feasibility of simultaneous PET/MRI through various imaging protocols in a total of 105 patients. All articles demonstrated equal or superior detection of liver lesions by PET/MRI over PET/CT. While one study reported superior detection of bone lesions by PET/MRI, two demonstrated favorable detection by PET/CT. Two studies demonstrated superiority of PET/CT in detection of nodal metastases; three studies reported the pitfall of PET/MRI in detection of lung lesion. Conclusion: The current literature reports successful technical feasibility of PET/MRI for imaging of NETs. While whole-body PET/CT in conjunction with an abdominal MRI may serve as a comprehensive approach for baseline staging, follow-up with PET/MRI may be preferred for those with liver-only disease. Another possible role for PET/MRI is to provide a multiparametric approach to follow-up of response to treatment. With further advances in MRI imaging acquisitions and post-processing techniques, PET/MRI may become more applicable to a broader group of patients with NETs, and possibly the imaging modality of choice for this patient population. © 2019, Italian Association of Nuclear Medicine and Molecular Imaging. |
| Keywords: | review; cancer patient; cancer radiotherapy; nuclear magnetic resonance imaging; positron emission tomography; magnetic resonance imaging; diagnostic accuracy; sensitivity and specificity; tumor localization; metastasis; image analysis; tumor volume; neuroendocrine tumor; diagnostic value; systematic review; image quality; ionizing radiation; radiosensitivity; clinical decision making; tracer; image processing; diffusion weighted imaging; gallium 68; chronic kidney failure; tumor diagnosis; liver injury; computed tomography; neuroendocrine tumors; standardized uptake value; human; priority journal |
| Journal Title: | Clinical and Translational Imaging |
| Volume: | 7 |
| Issue: | 6 |
| ISSN: | 2281-5872 |
| Publisher: | Springer |
| Date Published: | 2019-12-01 |
| Start Page: | 405 |
| End Page: | 413 |
| Language: | English |
| DOI: | 10.1007/s40336-019-00344-1 |
| PROVIDER: | scopus |
| PMCID: | PMC7717609 |
| PUBMED: | 33282794 |
| DOI/URL: | |
| Notes: | Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
60Riedl -
958Larson -
205Bodei -
70Mayerhoefer -
1Pirasteh
Related MSK Work