Curing all patients with acute promyelocytic leukemia: Are we there yet? Journal Article
| Authors: | Baljevic, M.; Park, J. H.; Stein, E.; Douer, D.; Altman, J. K.; Tallman, M. S. |
| Article Title: | Curing all patients with acute promyelocytic leukemia: Are we there yet? |
| Abstract: | The introduction of all-trans retinoic acid to anthracycline-based chemotherapy has revolutionized the prognosis of patients with acute promyelocytic leukemia (APL). The introduction of arsenic trioxide enabled the therapeutic approach of rationally targeted frontline protocols with minimal or no traditional cytotoxic chemotherapy and without compromise of previously established outstanding outcomes with anthracycline-based regimens. Although most of the current investigative efforts in APL are focused on developing potentially curative therapy without the exposure to toxicities and risks of DNA-disrupting agents, the cure rate can further be increased by implementing meticulous supportive care strategies that counter early coagulopathy-related deaths. © 2011 Elsevier Inc. |
| Keywords: | cancer chemotherapy; cancer survival; acute granulocytic leukemia; overall survival; neutropenia; review; drug dose reduction; drug efficacy; cancer patient; cytarabine; sensitivity and specificity; thrombocytopenia; relapse; hematopoietic stem cell transplantation; cancer mortality; high risk patient; arsenic trioxide; leukemia, promyelocytic, acute; cancer regression; minimal residual disease; neoplasm, residual; mitoxantrone; daunorubicin; promyelocytic leukemia; leukocyte count; flt3 ligand; anthracycline; convalescence; chromosome 17; induction chemotherapy; fibrinogen; thrombocyte transfusion; targeted therapies; autologous bone marrow transplantation; acute promyelocytic leukemia; retinoic acid receptor alpha; promyelocyte; cryoprecipitate; molecularly targeted therapy; fresh frozen plasma; all-trans retinoic acid; cure; chromosome 15; maintenance chemotherapy; consolidation chemotherapy; tamibarotene |
| Journal Title: | Hematology/Oncology Clinics of North America |
| Volume: | 25 |
| Issue: | 6 |
| ISSN: | 0889-8588 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2011-12-01 |
| Start Page: | 1215 |
| End Page: | 1233 |
| Language: | English |
| DOI: | 10.1016/j.hoc.2011.10.002 |
| PROVIDER: | scopus |
| PUBMED: | 22093584 |
| PMCID: | PMC4021483 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 9 December 2011" - "CODEN: HCNAE" - "Source: Scopus" |
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