Melanoma risk stratification of individuals with a high-risk naevus phenotype - A pilot study Journal Article


Authors: Rishpon, A.; Navarrete-Dechent, C.; Marghoob, A. A.; Dusza, S. W.; Isman, G.; Kose, K.; Halpern, A. C.; Marchetti, M. A.
Article Title: Melanoma risk stratification of individuals with a high-risk naevus phenotype - A pilot study
Abstract: Background/Objectives: High a naevus counts and atypical naevi are risk factors for cutaneous melanoma. However, many individuals with a high-risk naevus phenotype do not develop melanoma. In this study, we describe the clinical and dermoscopic attributes of naevi associated with melanoma in a high-risk naevus phenotype population. Methods: This single-centre, hospital-based case–control study included 54 prospectively enrolled adult patients ≥18 years old with a high-risk naevus phenotype (18 cases with a history of melanoma and 36 age- and gender-matched controls without a history of melanoma). We analysed clinical and dermoscopic images of the 20 largest naevi for each participant. Results: Cases had a higher mean age than controls (48.2 vs. 39.1 years, P = 0.007) but there was no difference in the male-to-female ratio between groups. Nearly, all participants (97%) were Fitzpatrick skin type II or III. Naevi in cases were more likely to be truncal, (72.6% vs. 53.6%, P = 0.01), particularly anterior truncal, (29.2% vs. 14.4%, P < 0.001) and larger than 8 mm (17.4% vs. 7.8%%, P = 0.01) compared to controls. CASH score of naevi did not differ between groups. Naevi in cases were more likely to have a multicomponent dermoscopic pattern than in controls (18.4% vs. 12.6%, P = 0.02). Conclusion: Larger naevi, truncal naevi, and naevi, with a multicomponent dermoscopic pattern may be risk factors for melanoma among individuals with a high-risk naevus phenotype. Further studies are needed to validate these findings. © 2019 The Australasian College of Dermatologists
Keywords: adult; controlled study; middle aged; major clinical study; case control study; cancer risk; prospective study; disease association; tumor localization; melanoma; dermoscopy; nevus; risk factor; high risk patient; risk; pilot study; risk stratification; dermatoscopy; naevi; human; male; female; article; dysplastic naevus syndrome
Journal Title: Australasian Journal of Dermatology
Volume: 60
Issue: 4
ISSN: 0004-8380
Publisher: Wiley Blackwell  
Date Published: 2019-11-01
Start Page: e292
End Page: e297
Language: English
DOI: 10.1111/ajd.13039
PUBMED: 30941757
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 2 December 2019 -- Source: Scopus
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MSK Authors
  1. Allan C Halpern
    328 Halpern
  2. Stephen Dusza
    199 Dusza
  3. Ashfaq A Marghoob
    436 Marghoob
  4. Kivanc Kose
    41 Kose