MEK inhibitors in lung cancer - You can teach an old drug new tricks Editorial

  


Author: Havel, J. J.
Title: MEK inhibitors in lung cancer - You can teach an old drug new tricks
Abstract: In this issue of Cancer Research, Xie and colleagues reveal an unexpected synergy between MEK inhibitors and immune checkpoint blockade in non–small cell lung cancer (NSCLC). Small-molecule inhibition of MEK led to increased cell surface expression of TNF receptor-1 (TNFR1) and sensitized NSCLC cells to cytokine-induced apoptosis. This study provides preclinical rationale for exploring the combination of MAPK pathway inhibitors with immunotherapy in NSCLC, independent of KRAS mutation status. 2019 American Association for Cancer Research.
Keywords: signal transduction; cancer survival; protein expression; protein phosphorylation; gene mutation; review; drug efficacy; monotherapy; nonhuman; t lymphocyte; stat3 protein; cancer immunotherapy; melanoma; apoptosis; enzyme inhibition; gene expression; biological model; tumor necrosis factor receptor 1; tumor necrosis factor receptor 2; tumor biopsy; immunoglobulin enhancer binding protein; in vivo study; caspase 3; antineoplastic activity; cytotoxicity; enzyme activation; tumor xenograft; enzyme activity; transcriptomics; cytokine; gamma interferon; melanoma cell; cell migration; epithelium cell; intestine epithelium cell; cytokine production; caspase 8; upregulation; oncogene k ras; tumor growth; internalization; enzyme mechanism; tumor necrosis factor; cell surface; non small cell lung cancer; tumor microenvironment; b raf kinase inhibitor; enzyme repression; mitogen activated protein kinase kinase inhibitor; mapk signaling; tumor necrosis factor receptor associated factor 2; human; priority journal; lung cancer cell line; melanoma cell line; crispr-cas9 system; lung non-small cell carcinoma cell line; duodenum epithelium
Journal Title: Cancer Research
Volume: 79
Issue: 22
ISSN: 0008-5472
Publisher: American Association for Cancer Research  
Date Published: 2019-11-01
Start Page: 5699
End Page: 5701
Language: English
DOI: 10.1158/0008-5472.Can-19-2590
PROVIDER: scopus
PUBMED: 31772071
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075084041&doi=10.1158%2f0008-5472.CAN-19-2590&partnerID=40&md5=5aedb28be72e08aa764ffb1584f2b7f6
Notes: Source: Scopus
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  1. Jonathan Joseph Havel
    18 Havel
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