New targeted therapies for metastatic non-small cell lung cancer Editorial


Author: Riely, G. J.
Title: New targeted therapies for metastatic non-small cell lung cancer
Abstract: Biomarker testing is essential for the management of patients with metastatic non-small cell lung cancer (NSCLC) to identify specific actionablemutations and guide treatment decisions in EGFR-mutant disease and for the potential benefit of combining tyrosine kinase inhibitors with chemotherapy to improve progression-free survival. For instance, for patients with EGFR exon 20 insertions, the role of amivantamab, an EGFR-MET-bispecific antibody, is being explored in the first-line and second-line settings, in addition to the use of ROS1 inhibitors, such as repotrectinib, in the treatment of ROS1-rearranged NSCLC. For patients with BRAF V600E mutations, combining BRAF and MEK inhibitors, such as dabrafenib and trametinib or encorafenib and binimetinib, has demonstrated efficacy. The potential of the antibody-drug conjugate fam-trastuzumab deruxtecan-nxki in treating HER2-mutant NSCLC is under investigation. Finally, for patients with KRAS G12C mutations, sotorasib and adagrasib have been tested as second-line therapies, with ongoing trials evaluating their use in the first-line setting.
Journal Title: Journal of the National Comprehensive Cancer Network
Volume: 22
Issue: Suppl.
ISSN: 1540-1405
Publisher: Harborside Press  
Date Published: 2024-05-01
Start Page: e245007
Language: English
ACCESSION: WOS:001276868500007
DOI: 10.6004/jnccn.2024.5007
PROVIDER: wos
Notes: Source: Wos
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  1. Gregory J Riely
    601 Riely