Clinical applications of breast cancer metabolomics using high-resolution magic angle spinning proton magnetic resonance spectroscopy (HRMAS 1H MRS): Systematic scoping review Journal Article

  

Authors:	Bitencourt, A. G. V.; Goldberg, J.; Pinker, K.; Thakur, S. B.
Article Title:	Clinical applications of breast cancer metabolomics using high-resolution magic angle spinning proton magnetic resonance spectroscopy (HRMAS 1H MRS): Systematic scoping review
Abstract:	Introduction: Breast cancer is a heterogeneous disease with different prognoses and responses to systemic treatment depending on its molecular characteristics, which makes it imperative to develop new biomarkers for an individualized diagnosis and personalized oncological treatment. Ex vivo high-resolution magic angle spinning proton magnetic resonance spectroscopy (HRMAS 1H MRS) is the most common technique for metabolic quantification in human surgical and biopsy tissue specimens. Objective: To perform a review of the current available literature on the clinical applications of HRMAS 1H MRS metabolic analysis in tissue samples of breast cancer patients. Methods: This systematic scoping review included original research papers published in the English language in peer-reviewed journals. Study selection was performed independently by two reviewers and preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines were followed. Results: The literature search returned 159 studies and 26 papers were included as part of this systematic review. There was considerable variation regarding tissue type, aims, and statistical analysis methods across the different studies. To facilitate the interpretation of the results, the included studies were grouped according to their aims or main outcomes into: feasibility and tumor diagnosis (n = 6); tumor heterogeneity (n = 2); correlation with proteomics/transcriptomics (n = 3); correlation with prognostic factors (n = 11); and response evaluation to NAC (n = 4). Conclusion: There is a lot of potential in including metabolic information of breast cancer tissue obtained with HRMAS 1H MRS. To date, studies show that metabolic concentrations quantified by this technique can be related to the diagnosis, prognosis, and treatment response in breast cancer patients. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
Keywords:	treatment response; review; doxorubicin; fluorouracil; lymph node metastasis; sensitivity and specificity; ki 67 antigen; breast cancer; tumor volume; cyclophosphamide; breast neoplasms; proteomics; transcriptomics; histology; feasibility study; systematic review; breast carcinoma; magnetic resonance spectroscopy; choline; epirubicin; neoadjuvant chemotherapy; estrogen receptor; progesterone receptor; anthracycline; tumor diagnosis; phosphatidylcholine; proton nuclear magnetic resonance; phosphorylcholine; metabolomics; clinical outcome; cancer prognosis; human epidermal growth factor receptor 2 positive breast cancer; tissue metabolism; high resolution magic angle spinning proton magnetic resonance spectroscopy; human; female; positron emission tomography-computed tomography; metabolic fingerprinting
Journal Title:	Metabolomics
Volume:	15
Issue:	11
ISSN:	1573-3882
Publisher:	Springer
Date Published:	2019-11-01
Start Page:	148
Language:	English
DOI:	10.1007/s11306-019-1611-5
PUBMED:	31696341
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074696654&doi=10.1007%2fs11306-019-1611-5&partnerID=40&md5=f1ecb224d7cbf089519964dc5f8b8428
Notes:	Review -- Source: Scopus

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