Repairing DNA damage in xeroderma pigmentosum: T4N5 lotion and gene therapy Journal Article
| Authors: | Zahid, S.; Brownell, I. |
| Article Title: | Repairing DNA damage in xeroderma pigmentosum: T4N5 lotion and gene therapy |
| Abstract: | Patients with xeroderma pigmentosum (XP) have defective DNA repair and are at a high risk for cutaneous malignancies. Standard treatments for XP are limited in scope and effectiveness. Understanding the molecular etiology of XP has led to the development of novel therapeutic approaches, including enzyme and gene therapies. One new topical treatment utilizing bacteriophage T4 endonuclease 5 (T4N5) in a liposomal lotion is currently in clinical trials and has received a Fast Track designation from the FDA. Gene therapy for XP, while making leaps in preclinical studies, has been slower to develop due to tactical hurdles, but seems to have much potential for future treatment. If these treatments prove effective in lowering the risk of cancer in patients with XP, they may also be found useful in reducing skin cancers in other at-risk patient populations. Copyright © 2008 Journal of Drugs in Dermatology. |
| Keywords: | genetics; review; mouse; animal; animals; mice; dna damage; dna repair; skin neoplasms; administration, topical; in vitro study; skin tumor; gene therapy; xeroderma pigmentosum; liposome; liposomes; virus protein; viral proteins; deoxyribodipyrimidine photolyase; deoxyribonuclease (pyrimidine dimer); endonuclease v, phage t4; topical drug administration; deoxyribodipyrimidine photo-lyase |
| Journal Title: | Journal of Drugs in Dermatology |
| Volume: | 7 |
| Issue: | 4 |
| ISSN: | 1545-9616 |
| Publisher: | Journal of Drugs in Dermatology, Inc. |
| Date Published: | 2008-04-01 |
| Start Page: | 405 |
| End Page: | 408 |
| Language: | English |
| PUBMED: | 18459526 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 17 November 2011" - "Source: Scopus" |
