Long-term cardiac and pulmonary complications of cancer therapy Journal Article
| Authors: | Yahalom, J.; Portlock, C. S. |
| Article Title: | Long-term cardiac and pulmonary complications of cancer therapy |
| Abstract: | Cardiac complications resulting from chemotherapy and radiation pose a significant risk for morbidity and mortality to the cancer survivor. Cardiac side effects may progress over time and are a concern for patients treated during childhood. Long-term pulmonary complications are relatively infrequent, and acute respiratory effects of drugs (mostly bleomycin) or radiation normally resolve early after therapy. Although most cardiovascular risk statistics and clinical experience are derived from patients treated before 1985, the modern radiation approach that limits the exposure of the heart and reduces the total dose seems to attenuate the previously observed cardiovascular risk. Potential preventive measures for high-risk patients are of increasing interest but remain experimental. © 2008 Elsevier Inc. All rights reserved. |
| Keywords: | cancer chemotherapy; prednisone; review; doxorubicin; fluorouracil; nonhuman; paclitaxel; cancer radiotherapy; methotrexate; rituximab; clinical practice; neoplasms; dacarbazine; lung toxicity; breast cancer; heart disease; antineoplastic combined chemotherapy protocols; radiotherapy; cyclophosphamide; vincristine; vinblastine; hodgkin disease; cancer survivor; survivors; docetaxel; cardiovascular risk; cardiotoxicity; mitoxantrone; daunorubicin; lung; long term care; bleomycin; epirubicin; idarubicin; taxane derivative; trastuzumab; anthracycline; heart; ischemic heart disease; cardiomyopathy; pericarditis; heart diseases; preventive medicine; lung diseases; valvular heart disease; razoxane; cardiotoxins |
| Journal Title: | Hematology/Oncology Clinics of North America |
| Volume: | 22 |
| Issue: | 2 |
| ISSN: | 0889-8588 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2008-04-01 |
| Start Page: | 305 |
| End Page: | 318 |
| Language: | English |
| DOI: | 10.1016/j.hoc.2008.01.010 |
| PUBMED: | 18395152 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 10" - "Export Date: 17 November 2011" - "CODEN: HCNAE" - "Source: Scopus" |
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