Post-translational regulation of PTEN Journal Article
| Authors: | Wang, X.; Jiang, X. |
| Article Title: | Post-translational regulation of PTEN |
| Abstract: | PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor regulates a variety of cellular processes including cell proliferation, growth, migration and death. This master regulator itself is also under deliberative regulation. Although the evidence for PTEN regulation and its significance in normal biology and disease is overwhelming, the mechanisms and exact functional consequences of PTEN regulation are far from clear. In this review, we discuss recent advances concerning post-translational regulation of PTEN in general, and in more detail about its regulation by ubiquitination. We also discuss some unsolved questions in the field and how they might be addressed in the future. We propose that the complex regulatory mechanisms of PTEN dictate how this tumor suppressor executes its distinct biological functions. © 2008 Macmillan Publishers Limited All rights reserved. |
| Keywords: | protein expression; unclassified drug; gene mutation; review; nonhuman; protein domain; protein motif; neoplasms; animals; biomedical research; models, biological; carboxy terminal sequence; protein protein interaction; protein; protein stability; genetic transcription; cell population; cancer research; dna methylation; tumor suppressor gene; protein processing; ubiquitination; protein processing, post-translational; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; pten phosphohydrolase; tumor suppressor; pten; tumor suppressor protein; phosphatidylinositol 3,4,5 trisphosphate; subpopulation; post-translational modification; protein-protein interaction; neural precursor expressed developmentally downregulated 4 1 protein |
| Journal Title: | Oncogene |
| Volume: | 27 |
| Issue: | 41 |
| ISSN: | 0950-9232 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2008-09-15 |
| Start Page: | 5454 |
| End Page: | 5463 |
| Language: | English |
| DOI: | 10.1038/onc.2008.242 |
| PUBMED: | 18794880 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 21" - "Export Date: 17 November 2011" - "CODEN: ONCNE" - "Source: Scopus" |
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