PTEN: A default gate-keeping tumor suppressor with a versatile tail Journal Article
| Authors: | Wang, X.; Jiang, X. |
| Article Title: | PTEN: A default gate-keeping tumor suppressor with a versatile tail |
| Abstract: | The tumor suppressor PTEN controls a variety of biological processes including cell proliferation, growth, migration, and death. As a master cellular regulator, PTEN itself is also subjected to deliberated regulation to ensure its proper function. Defects in PTEN regulation have a profound impact on carcinogenesis. In this review, we briefly discuss recent advances concerning PTEN regulation and how such knowledge facilitates our understanding and further exploration of PTEN biology. The carboxyl-tail of PTEN, which appears to be associated with multiple types of posttranslational regulation, will be under detailed scrutiny. Further, a comparative analysis of PTEN and p53 suggests while p53 needs to be activated to suppress tumorigenesis (a dormant gatekeeper), PTEN is probably a constitutive surveillant against cancer development, thus a default gatekeeper. © 2008 IBCB, SIBS, CAS All rights reserved. |
| Keywords: | genetics; review; animal; metabolism; animals; ubiquitin protein ligase; protein p53; physiology; cell transformation, neoplastic; gene expression regulation; gene expression regulation, neoplastic; chemistry; protein processing; ubiquitination; protein processing, post-translational; cell transformation; tumor suppressor proteins; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; pten phosphohydrolase; tumor suppressor protein p53; protein structure, tertiary; tumor suppressor; pten; tumor suppressor protein; ubiquitin-protein ligases; protein tertiary structure; p53; nedd4 ubiquitin protein ligases; posttranslational regulation; pyronia tithonus |
| Journal Title: | Cell Research |
| Volume: | 18 |
| Issue: | 8 |
| ISSN: | 1001-0602 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2008-08-01 |
| Start Page: | 807 |
| End Page: | 816 |
| Language: | English |
| DOI: | 10.1038/cr.2008.83 |
| PUBMED: | 18626510 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 8" - "Export Date: 17 November 2011" - "Source: Scopus" |
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