Scleromyxedematous changes in a patient with long-standing mycosis fungoides who progressed to Sézary syndrome Journal Article


Authors: Miraflor, A. P.; Pulitzer, M. P.; Myskowski, P. L.; Geller, S.
Article Title: Scleromyxedematous changes in a patient with long-standing mycosis fungoides who progressed to Sézary syndrome
Abstract: Mycosis fungoides (MF) variants with different clinicopathologic and immunohistochemical features have been well-delineated. We report a case of scleromyxedematous changes arising in a patient with long-standing MF who progressed to Sézary syndrome (SS) shortly afterward. Total-skin electron-beam radiation therapy resulted in an excellent response, controlling both the MF/SS and the scleromyxedematous lesions; however, the patient died few months later. Although mucin deposition has been described in association with MF/SS (mainly follicular mucinosis in folliculotropic MF), there are limited reports in the literature on dermal mucinosis and scleromyxedematous changes in MF/SS. The mechanism of this association and its prognostic implications requires further investigation.
Journal Title: American Journal of Dermatopathology
Volume: 41
Issue: 11
ISSN: 0193-1091
Publisher: Lippincott Williams & Wilkins  
Date Published: 2019-11-01
Start Page: e139
End Page: e143
Language: English
DOI: 10.1097/dad.0000000000001464
PUBMED: 31169525
PROVIDER: scopus
PMCID: PMC6803053
DOI/URL:
Notes: Article -- Export Date: 1 November 2019 -- Source: Scopus
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MSK Authors
  1. Melissa P Pulitzer
    203 Pulitzer
  2. Patricia Myskowski
    216 Myskowski
  3. Shamir Geller
    53 Geller