Racial disparities in mycosis fungoides/Sézary syndrome–A single-center observational study of 292 patients Journal Article
| Authors: | Gandham, A. R.; Geller, S.; Dusza, S. W.; Kupper, T. S.; Myskowski, P. L. |
| Article Title: | Racial disparities in mycosis fungoides/Sézary syndrome–A single-center observational study of 292 patients |
| Abstract: | Background: Clinical presentation of Mycosis fungoides/Sézary syndrome (MF/SS) in Black and African American (AA) patients can be heterogeneous with poor survival reported in AA/black patients. In this study, we aim to characterize differences between AA/black and white patients with MF/SS. Patients and Methods: A retrospective single-center hospital-based case-control study including 292 MF/SS patients (146 AA/black matched with 146 white patients). We analyzed demographic, clinical and survival differences. Results: AA/black patients were diagnosed at an earlier age (9 years younger), were predominantly females, had higher rates of Medicaid/Medicare insurance and lower income compared to matched white patients (P <.001). Adjusting for age, sex, insurance type, and income bracket, AA/black patients had significantly worse overall survival (hazard ratio [HR] 2.88, 95%CI 1.21-6.85, P = .017). Association of clinical MF phenotype with survival showed that hypopigmentation was associated with survival in AA/black patients but not in white patients. Erythroderma and ulceration were associated with worse survival risk in AA/black patients. Conclusions: AA/black patients with MF/SS have a significant worse survival outcome compared to white patients. The association between clinical phenotypes and survival differed between these groups. Further studies are required to investigate whether race-specific pathogenesis or genetic factors may explain these differences. © 2024 Elsevier Inc. |
| Keywords: | survival; adult; child; controlled study; aged; middle aged; survival analysis; retrospective studies; major clinical study; case control study; case-control studies; clinical feature; united states; skin neoplasms; pathology; retrospective study; social status; medicaid; medicare; cutaneous t cell lymphoma; skin tumor; erythema; hyperpigmentation; papule; epidemiology; observational study; racial disparity; mycosis fungoides; african american; ulcer; caucasian; hypopigmentation; sezary syndrome; hospital based case control study; cutaneous lymphoma; lymphoma, t-cell, cutaneous; ctcl; erythroderma; humans; human; male; female; article; black person; poikiloderma; household income; mf; skin of color |
| Journal Title: | Clinical Lymphoma, Myeloma and Leukemia |
| Volume: | 24 |
| Issue: | 4 |
| ISSN: | 2152-2650 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2024-04-01 |
| Start Page: | e174 |
| End Page: | e180 |
| Language: | English |
| DOI: | 10.1016/j.clml.2023.12.017 |
| PUBMED: | 38245472 |
| PROVIDER: | scopus |
| PMCID: | PMC10981557 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK author: Shamir Geller -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work