Evaluation of CA M26, CA M29, CA 15-3 and CEA as circulating tumor markers in breast cancer patients Journal Article


Authors: Dnistrian, A. M.; Schwartz, M. K.; Greenberg, E. J.; Smith, C. A.; Schwartz, D. C.
Article Title: Evaluation of CA M26, CA M29, CA 15-3 and CEA as circulating tumor markers in breast cancer patients
Abstract: The clinical utility of CA M26 and CA M29 was studied in 116 breast cancer patients and compared with results for CA 15-3 and carcinoembryonic antigen (CEA). The highest sensitivities for breast cancer detection were achieved with CA 15-3 (0.60) and CEA (0.56), but this was compromised by a relative lack of specificity (0.87 and 0.88 for CA 15-3 and CEA, respectively). Sensitivities attained with CA M26 (0.47) and CA M29 (0.53) were lower, but there was an excellent specificity (1.00) for each assay in this series of benign patients. Tumor marker elevations were appreciable with advanced disease such that 82 of 91 patients (90%) with active metastatic breast cancer exhibited at least one abnormal test value. Longitudinal studies demonstrated that CA M26, CA M29, CA 15-3 and CEA complement each other and combinations of these markers reflect disease status better than individual tests. © 1991 S. Karger AG, Basel.
Keywords: adult; controlled study; major clinical study; case report; comparative study; sensitivity and specificity; breast cancer; carcinoembryonic antigen; smoking; breast neoplasms; tumor antigen; monoclonal antibodies; monoclonal antibody; longitudinal studies; antigens, neoplasm; reference values; neoplasm metastasis; immunoassay; antigens, tumor-associated, carbohydrate; blood level; mucin; middle age; tumor markers; tumor-associated antigens; ca 15-3 antigen; prognosis; human; female; article; mucoproteins; support, non-u.s. gov't; mucin type glycoprotein
Journal Title: Tumor Biology
Volume: 12
Issue: 2
ISSN: 1010-4283
Publisher: Springer Netherlands  
Date Published: 1991-01-01
Start Page: 82
End Page: 90
Language: English
DOI: 10.1159/000217692
PUBMED: 2028182
PROVIDER: scopus
DOI/URL:
Notes: Source: Scopus
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MSK Authors
  1. Morton Schwartz
    176 Schwartz
  2. Carol   Smith
    38 Smith