CA 15-3 and carcinoembryonic antigen in the clinical evaluation of breast cancer Journal Article

  


Authors: Dnistrian, A. M.; Schwartz, M. K.; Greenberg, E. J.; Smith, C. A.; Schwartz, D. C.
Article Title: CA 15-3 and carcinoembryonic antigen in the clinical evaluation of breast cancer
Abstract: The individual and combined value of CA 15-3 and carcinoembryonic antigen (CEA) as breast cancer tumor markers was investigated in longitudinal studies. Patients included women at high risk for recurrence after primary therapy or undergoing treatment for metastatic disease. During follow-up, recurrent disease was documented in 33 of 39 (85%) patients including 11 with local recurrence and 22 with distant metastases. At the time recurrence was first documented by objective criteria 23 of 33 (70%) of the patients presented with abnormal CA 15-3 levels (>36.7 U/ml) compared with 19/33 (58%) with abnormal CEA levels (5 ng/ml). Tumor marker elevations predominated in patients with advanced disease indicating that CA 15-3 and CEA are not reliable for the detection of early breast cancer. Both markers were helpful in monitoring therapeutic response since antigen levels correlated closely with disease status. © 1991.
Keywords: clinical article; neoplasm recurrence, local; breast cancer; carcinoembryonic antigen; tumor markers, biological; breast neoplasms; tumor marker; time factors; immunoenzyme techniques; longitudinal studies; antigens, neoplasm; neoplasm metastasis; predictive value of tests; ca 15-3 antigen; cea; human; male; female; priority journal; article; ca15-3; carcinoma associated mucin antigens
Journal Title: Clinica Chimica Acta
Volume: 200
Issue: 2-3
ISSN: 0009-8981
Publisher: Elsevier Science BV  
Date Published: 1991-08-30
Start Page: 81
End Page: 93
Language: English
DOI: 10.1016/0009-8981(91)90080-v
PUBMED: 1777973
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025879077&doi=10.1016%2f0009-8981%2891%2990080-V&partnerID=40&md5=7e33444c8bcac5a4c8e26e587eca5806
Notes: Article -- Export Date: 27 September 2019 -- Source: Scopus
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MSK Authors
  1. Ann Dnistrian
    78 Dnistrian
  2. Morton Schwartz
    186 Schwartz
  3. Delia C Schwartz
    45 Schwartz
  4. Carol Smith
    39 Smith
  5. Ernest J. Greenberg
    17 Greenberg
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