Synthesis of glyfoline, a constituent of Glycosmis citrifolia (Willd.) Lindl. and a potential anticancer agent Journal Article
| Authors: | Su, T. L.; Dziewiszek, K.; Wu, T. S. |
| Article Title: | Synthesis of glyfoline, a constituent of Glycosmis citrifolia (Willd.) Lindl. and a potential anticancer agent |
| Abstract: | Condensation of 4-benzyloxy-3-methoxyanthranilic acid (3) with 5-iodo-1,2,3,4-tetramethoxybenzene (4) gave 6-benzyloxy-1,2,3,4,5-pentamethoxy-9-acridone (5), which was then converted into glyfoline (1) via N-methylation, selective de-O-methylation, and debenzylation. The synthetic glyfoline (1) is identical with an authentic sample isolated from plant. © 1991. |
| Keywords: | unclassified drug; antineoplastic agent; drug synthesis; acridine derivative; priority journal; article; glyfoline; glycosmis parviflora |
| Journal Title: | Tetrahedron Letters |
| Volume: | 32 |
| Issue: | 12 |
| ISSN: | 0040-4039 |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Date Published: | 1991-03-18 |
| Start Page: | 1541 |
| End Page: | 1544 |
| Language: | English |
| DOI: | 10.1016/s0040-4039(00)74267-5 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
