Synthetic and antiviral studies of certain acyclic 3'-azido-3'-deoxythymidine (AZT) analogues Journal Article
| Authors: | Lee, K. H.; Chen, Y. L.; Huang, B. R.; Tzeng, C. C.; Zhu, Q. Y.; Chou, T. C. |
| Article Title: | Synthetic and antiviral studies of certain acyclic 3'-azido-3'-deoxythymidine (AZT) analogues |
| Abstract: | A direct alkylation of trimethylsilylated pyrimidines and azapyrimidines with 1-azido-3-benzyloxy-2-chloromethoxypropane gave acyclic analogues of AZT in a good overall yield. None of the compounds exhibited significant antiviral activity against human immunodeficiency virus and herpes simplex virus. © 1991, Taylor & Francis Group, LLC. All rights reserved. |
| Keywords: | simplexvirus; antivirus agent; human immunodeficiency virus; herpes simplex virus; herpes; synthesis; antiviral activity; zidovudine; article; zidovudine derivative |
| Journal Title: | Nucleosides & Nucleotides |
| Volume: | 10 |
| Issue: | 6 |
| ISSN: | 0732-8311 |
| Publisher: | Taylor & Francis Inc. |
| Date Published: | 1991-01-01 |
| Start Page: | 1407 |
| End Page: | 1416 |
| Language: | English |
| DOI: | 10.1080/07328319108047070 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
