The response of ataxia-telangiectasia lymphoblastoid cells to neutron irradiation Journal Article
| Authors: | Houldsworth, J.; Cohen, D.; Singh, S.; Lavin, M. F. |
| Article Title: | The response of ataxia-telangiectasia lymphoblastoid cells to neutron irradiation |
| Abstract: | The response of control and ataxia-telangiectasia (A-T) cells to increasing doses of high-linear-energy-transfer (LET) ionizing radiation (neutrons) was compared. Ataxia-telangiectasia cells were markedly more sensitive to neutron irradiation than were control cells. The D0 value for the two A-T cell lines was 0.4 Gy while the value for controls was approximately 1.4 Gy. East neutrons were considerably more effective than γ rays in inducing cell death in both cell types, but the sensitivity factor remained approximately the same as with γ rays. A minimal depression of DNA synthesis was observed in ataxia-telangiectasia cells after neutron irradiation, similar to that reported previously after γ irradiation. The extent of inhibition was not significantly greater in control cells, contrary to that seen with γ rays. In time-course experiments a significant difference in degree of inhibition of DNA synthesis was observed between the cell types. Low doses of fast neutrons induced a G2-phase delay in both cell types, but the degree and extent of this delay was greater in ataxia-telangiectasia cells as observed previously with low-LET radiation. |
| Keywords: | controlled study; human cell; radiosensitivity; ataxia; ataxia telangiectasia; lymphoblastoid cell; human; priority journal; article; fast neutron radiation |
| Journal Title: | Radiation Research |
| Volume: | 125 |
| Issue: | 3 |
| ISSN: | 0033-7587 |
| Publisher: | Radiation Research Society |
| Date Published: | 1991-03-01 |
| Start Page: | 277 |
| End Page: | 282 |
| Language: | English |
| DOI: | 10.2307/3578110 |
| PUBMED: | 2000451 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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