Diffuse large cell lymphoma. Prognostic factors with treatment Conference Paper
| Authors: | Straus, D. J.; Wong, G.; Yahalom, J.; Varsos, G.; Gulati, S.; Clarkson, B. |
| Title: | Diffuse large cell lymphoma. Prognostic factors with treatment |
| Conference Title: | 2nd Vicenza International Workshop of Hematology |
| Abstract: | Five successive chemotherapy protocols for stages II, III and IV diffuse large cell lymphoma (DLCL) have resulted in identical overall survivals. Between 35% to 45% of patients survived. In a multivariate analysis employing the Weibull model 3 factors were associated with shortened survival: bulky mediastinal and/or retroperitoneal disease, elevated serum LDH and advanced age. In young patients with bulky mediastinal and/or retroperitoneal disease and high serum LDH, autologous bone marrow transplantation following high dose chemotherapy and radiation therapy (RT) as part of the initial-treatment have produced more promising results. In a randomized trial, a significantly longer disease-free survival was found for patients with stages I or IE diffuse lymphomas with RT followed by adjuvant chemotherapy than with RT alone. |
| Keywords: | adult; cancer survival; survival analysis; major clinical study; prednisone; clinical feature; cancer localization; doxorubicin; cancer combination chemotherapy; treatment planning; conference paper; combined modality therapy; cytarabine; methotrexate; paraaortic lymph node; antineoplastic combined chemotherapy protocols; cyclophosphamide; vincristine; patient monitoring; pathology; age; cancer regression; folinic acid; bleomycin; lactate dehydrogenase; multivariate analysis; large cell lymphoma; lactate dehydrogenase blood level; middle age; retroperitoneal disease; lymphoma, large-cell, diffuse; prognosis; human; male; female; priority journal |
| Journal Title | Leukemia |
| Volume: | 5 |
| Issue: | Suppl. 1 |
| Conference Dates: | 1991 May 29-31 |
| Conference Location: | Vicenze, Italy |
| ISBN: | 0887-6924 |
| Publisher: | Nature Publishing Group |
| Date Published: | 1991-01-01 |
| Start Page: | 32 |
| End Page: | 36 |
| Language: | English |
| PUBMED: | 1890863 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
