Autologous bone marrow transplantation for patients with poor-prognosis lymphoma Journal Article
| Authors: | Gulati, S. C.; Shank, B.; Black, P.; Yopp, J.; Koziner, B.; Straus, D.; Filippa, D.; Kempin, S.; Castro-Malaspina, H.; Cunningham, I.; Berman, E.; Coleman, M.; Langleben, A.; Colvin, O. M.; Fuks, Z.; O'Reilly, R.; Clarkson, B. |
| Article Title: | Autologous bone marrow transplantation for patients with poor-prognosis lymphoma |
| Abstract: | Review of prognostic factors at Memorial Hospital in New York City has shown that adult patients with large-cell lymphoma (diffuse histiocytic lymphoma by Rappaport classification) who have high lactic dehydrogenase (LDH) and/or bulky mediastinal or abdominal disease are destined to do poorly with conventional combination chemotherapy, with a 2-year disease-free survival of about 20%. Patients who relapse after conventional combination chemotherapy have a similar poor prognosis. Thirty-one such patients with lymphoma were studied to evaluate the efficacy of intensive radiotherapy (hyperfractionated total body irradiation [TBI] [1,320 rad]), and cyclophosphamide (60 mg/kg/d for two days) followed by autologous bone marrow transplantation (ABMT). Our results show a disease-free survival advantage (P = .002) for 14 patients who underwent ABMT immediately after induction of remission with 79% surviving at a median follow-up 49.2+ months, compared with a median survival of 5.2 months for 17 patients administered ABMT while in relapse and/or after failing conventional treatment. Our results support the use of aggressive therapy as early treatment for patients with poor prognostic features. |
| Keywords: | survival; adolescent; adult; clinical article; methodology; relapse; cyclophosphamide; lymphoma; remission; bone marrow transplantation; autotransplantation; prognosis; human; male; female; priority journal |
| Journal Title: | Journal of Clinical Oncology |
| Volume: | 6 |
| Issue: | 8 |
| ISSN: | 0732-183X |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 1988-08-01 |
| Start Page: | 1303 |
| End Page: | 1313 |
| Language: | English |
| DOI: | 10.1200/jco.1988.6.8.1303 |
| PUBMED: | 3045265 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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