A regional covariance approach to the analysis of functional patterns in positron emission tomographic data Conference Paper

  


Authors: Moeller, J. R.; Strother, S. C.
Title: A regional covariance approach to the analysis of functional patterns in positron emission tomographic data
Conference Title: PET Data Analysis Workshop
Abstract: This article provides a complete description of the subprofile scaling model (SSM) approach to the analysis of positron emission tomography (PET) data. The goals and assumptions underlying the development of SSM are outlined, and its strengths and weaknesses are discussed. It is demonstrated that all obtainable information about regional ratios can, in theory, be derived from the SSM regional covariance patterns. A general constraint on the ability to effectively remove global variation while identifying region-specific information about PET data sets is outlined and discussed within the SSM framework. Finally, an extension of the SSM technique to the generation of disease-specific covariance patterns is demonstrated for paraneoplastic cerebellar degeneration, the acquired immune deficiency syndrome dementia complex, and Parkinson's disease, and the importance of multidimensional descriptions of disease, such as may be obtained from PET data using SSM, is emphasized. Key Words:.
Keywords: conference paper; positron emission tomography; data interpretation, statistical; kinetics; brain; dementia; brain diseases; glucose; parkinson disease; analysis of variance; model; tomography, emission-computed; mathematical analysis; mathematics; cerebellar diseases; paraneoplastic syndromes; deoxyglucose; fludeoxyglucose f 18; human; priority journal; support, u.s. gov't, p.h.s.; aids dementia complex; subprofile scaling model
Journal Title Journal of Cerebral Blood Flow and Metabolism
Volume: 11
Issue: Suppl. 1
Conference Dates: 1989 May 1-2
Conference Location: New York, NY
ISBN: 0271-678X
Publisher: Sage Publications Ltd.  
Date Published: 1991-03-01
Start Page: A121
End Page: A135
Language: English
PUBMED: 1997480
PROVIDER: scopus
DOI: 10.1038/jcbfm.1991.47
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025969753&partnerID=40&md5=95650a86919f92962350818c120283cc
Notes: Article -- Export Date: 27 September 2019 -- Source: Scopus
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MSK Authors
  1. Stephen C. Strother
    24 Strother
  2. James Moeller
    17 Moeller
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