Detection of hepatic metastases from colorectal carcinoma using indium-111 ((111)In) labeled monoclonal antibody (mAB): MSKCC experience with mAb (111)In-C110 Journal Article

  

Authors:	Divgi, C. R.; McDermott, K.; Johnson, D. K.; Schnobrich, K. E.; Finn, R. D.; Cohen, A. M.; Larson, S. M.
Article Title:	Detection of hepatic metastases from colorectal carcinoma using indium-111 ((111)In) labeled monoclonal antibody (mAB): MSKCC experience with mAb (111)In-C110
Abstract:	Sixteen patients with colorectal carcinoma and a rising serum carcinoembryonic antigen (CEA) level and no evidence of extra-abdominal disease were administered 5 mg of an anti-CEA monoclonal antibody (mAb), C110, labeled with approx. 5 mCi of 111In. All patients subsequently underwent exploratory laparotomy, and samples of tumor and normal tissue were obtained. Hepatic lesions (confirmed by histopathology) were visualized as areas of increased radiotracer uptake in 13 of 16 patients. Single photon emission computed tomography (SPECT) considerably aided detection, being positive in two patients with normal planar images. Ten of the 16 patients had positive x-ray computed tomographic (CT) images. The radioimmunodiagnostic study was falsely negative in 3 of 16 patients with subsequently proven hepatic disease, in one of whom CT was also normal. The antibody study was positive in 80% of lesions, thus being, in this small series, significantly more sensitive (P < 0.01) than CT. 111In-C110 is a promising monoclonal antibody for the detection of hepatic metastases from colorectal carcinoma; this is the first study to show consistently greater concentration of 111In-labeled antibody in hepatic lesions than in surrounding normal hepatic parenchyma. © 1991.
Keywords:	adult; clinical article; controlled study; aged; colorectal cancer; liver metastasis; isotope labeling; single photon emission computer tomography; indium 111; intravenous drug administration; immunoscintigraphy; carcinoembryonic antibody; human; male; female; priority journal; article
Journal Title:	International Journal of Radiation Applications and Instrumentation. Part B: Nuclear Medicine and Biology
Volume:	18
Issue:	7
ISSN:	0883-2897
Publisher:	Elsevier, Inc.
Date Published:	1991-01-01
Start Page:	705
End Page:	707, 709-710
Language:	English
DOI:	10.1016/0883-2897(91)90008-9
PUBMED:	1787079
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-44949282187&doi=10.1016%2f0883-2897%2891%2990008-9&partnerID=40&md5=46a02da92d6af66435124be99f7ff82a
Notes:	Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/154401