The value of gamma camera and computed tomography data set coregistration to assess Lewis Y antigen targeting in small cell lung cancer by 111Indium-labeled humanized monoclonal antibody 3S193 Journal Article

  

Authors:	Quaia, E.; Krug, L. M.; Pandit-Taskar, N.; Nagel, A.; Reuter, V. E.; Humm, J.; Divgi, C.
Article Title:	The value of gamma camera and computed tomography data set coregistration to assess Lewis Y antigen targeting in small cell lung cancer by 111Indium-labeled humanized monoclonal antibody 3S193
Abstract:	Aim: To assess the value of data set coregistration of gamma camera and computed tomography (CT) in the assessment of targeting of humanized monoclonal antibody 3S193 labeled with indium-111 (111In-hu3S193) to small cell lung cancer (SCLC). Methods and materials: Ten patients (6 male and 4 female; mean age ± S.D., 60 ± 4 years), from an overall population of 20 patients with SCLCs expressing Lewis Y antigen at immunohistochemical analysis, completed a four weekly injections of 111In-hu3S193 and underwent gamma camera imaging. All had had, as part of their baseline evaluation, Fluorine18 fluoro-2-deoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). Two readers in consensus retrospectively coregistered the gamma camera images with the CT component of the FDG PET/CT by automatic or manual alignment. The resulting image sets were visually examined and SCLC lesions targeting at coregistered gamma camera and CT was correlated side-by-side with the 18F-FDG uptake. Results: A total number of 31 lesions from SCLC with a thoracic (n = 13) or extrathoracic location (n = 18) were all positive on FDG PET/CT. Coregistration of the gamma camera to the CT demonstrated targeting of antibody to all lesions >2 cm (n = 20) and in a few lesions ≤2 cm (n = 2), with no visualization of most lesions ≤2 cm (n = 9). No 111In-hu3S193 uptake in normal tissues was observed. Conclusion: Coregistration of antibody gamma camera imaging to FDG PET/CT is feasible and allows valuable assessment of 111In-hu3S193 antibody targeting to SCLC lesions >2 cm, while lesions ≤2 cm reveal a limited targeting. © 2007 Elsevier Ireland Ltd. All rights reserved.
Keywords:	immunohistochemistry; adult; clinical article; controlled study; human tissue; treatment outcome; aged; middle aged; positron emission tomography; antigen expression; computer assisted tomography; lung neoplasms; tomography, x-ray computed; molecular imaging; monoclonal antibodies; lung small cell cancer; antibodies, monoclonal; indium radioisotopes; antigen; tissue distribution; whole body imaging; diagnostic value; computerized tomography; diagnostic radiography; medical imaging; tomography; pilot projects; fluorodeoxyglucose f 18; gamma cameras; drug absorption; tracer; antibodies; radioimmunotherapy; pet; image display; lewis blood-group system; small cell lung carcinoma; data sets; spect; computed tomography (ct); scintillation camera; history, 18th century; thermography (temperature measurement); humanized monoclonal antibody; lewis y antigen; cameras; x ray cameras; co-registration; computed tomography data; small cell lung cancer (sclc); humanized monoclonal antibody 3s193 in 111
Journal Title:	European Journal of Radiology
Volume:	67
Issue:	2
ISSN:	0720-048X
Publisher:	Elsevier B.V
Date Published:	2008-01-01
Start Page:	292
End Page:	299
Language:	English
DOI:	10.1016/j.ejrad.2007.07.004
PUBMED:	17714905
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-46749155866&partnerID=40&md5=9ae7bb23b671f1c820538e88b308741d
Notes:	--- - "Cited By (since 1996): 1" - "Export Date: 17 November 2011" - "CODEN: EJRAD" - "Source: Scopus"

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