The kit ligand encoded at the murine Steel locus: a pleiotropic growth and differentiation factor Journal Article
| Author: | Besmer, P. |
| Article Title: | The kit ligand encoded at the murine Steel locus: a pleiotropic growth and differentiation factor |
| Abstract: | The c-kit receptor and its recently identified ligand are allelic with the murine White Spotting and Steel loci, respectively. These observations brought to light the functions of the c-kit receptor system in melanogenesis, gametogenesis and hematopoeisis during embryogenesis and in postnatal life. The recent molecular analysis of several White Spotting and Steel alleles has provided insights into the mechanism of c-kit ligand-mediated processes, including cell proliferation, cell migration and cell survival. Furthermore, the availability of the kit ligand has allowed in vitro investigations of the pleiotropic functions of c-kit in development and cell differentiation to be carried out. © 1991. |
| Keywords: | signal transduction; oncoprotein; genetics; mutation; proto-oncogene proteins; review; mouse; phenotype; animal; metabolism; mice; stem cell factor receptor; embryology; morphogenesis; murinae; cell surface receptor; receptors, cell surface; support, non-u.s. gov't; proto-oncogene protein c-kit; proto oncogene protein c kit; proto oncogene proteins |
| Journal Title: | Current Opinion in Cell Biology |
| Volume: | 3 |
| Issue: | 6 |
| ISSN: | 0955-0674 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1991-12-01 |
| Start Page: | 939 |
| End Page: | 946 |
| Language: | English |
| DOI: | 10.1016/0955-0674(91)90111-b |
| PUBMED: | 1726043 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 September 2019 -- Source: Scopus |
