The future of cytokine combination therapy Conference Paper
| Author: | Moore, M. A. S. |
| Title: | The future of cytokine combination therapy |
| Conference Title: | A Visionary Assessment of the Scientific, Clinical, and Economic Implications of Hematopoietic Growth Factors |
| Abstract: | The hematopoietic growth factors including colony‐stimulating factors (CSF) and interleukins (IL) have overlapping and pleiotropic effects on proliferation and differentiation of progenitor cells and stem cells. The regulatory signals can influence terminal differentiation and the cell cycle status, self‐renewal, and differentiation of early pluripotential stem cells. Synergistic interactions between CSF and IL have been shown, both in vitro and in vivo, to be critical in hematopoietic regulation. The future of clinical trials of cytokines in congenital and acquired myelosuppressed states lies in the selective use of appropriate combinations of these regulatory macromolecules. Copyright © 1991 American Cancer Society |
| Keywords: | conference paper; animal; cells, cultured; anemia; granulocyte macrophage colony stimulating factor; cell differentiation; drug synergism; cytokines; drug combination; interleukin 6; hematopoiesis; granulocyte colony stimulating factor; colony-stimulating factors; interleukins; colony stimulating factor 1; hemopoietic growth factor; interleukin 1; futurology; interleukin 3; colony stimulating factor; human; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title | Cancer |
| Volume: | 67 |
| Issue: | Suppl. 10 |
| Conference Dates: | 1990 Aug 31 |
| Conference Location: | Seattle, WA |
| ISBN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 1991-05-15 |
| Start Page: | 2718 |
| End Page: | 2726 |
| Language: | English |
| DOI: | 10.1002/1097-0142(19910515)67:10+<2718::Aid-cncr2820671709>3.0.Co;2-3 |
| PUBMED: | 2015575 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 September 2019 -- Source: Scopus |
