Identification and characterization of receptors for tumor necrosis factor-α in the brain Journal Article

  


Authors: Kinouchi, K.; Brown, G.; Pasternak, G.; Donner, D. B.
Article Title: Identification and characterization of receptors for tumor necrosis factor-α in the brain
Abstract: Specific receptors for murine TNF have been identified in homogenates of rodent brain. These receptors are saturable and bind TNF with sufficient affinity to ensure occupancy by cytokine elaborated during infection. 125I-mTNF was detected in four specific complexes of Mr 130,000, 90,000, 66,000 and 60,000 after affinity labeling. Solubilization of brain membranes into detergent increased binding capacity 4-fold which indicates the presence of latent receptors for mTNF in the brain. Specific binding was greatest in the brainstem, least in the cerebellum and was also detected in the cortex, thalamus and basal ganglia. © 1991.
Keywords: nonhuman; mouse; animal; mice; animal tissue; cerebellum; tumor necrosis factor alpha; kinetics; brain; recombinant proteins; cell membrane; organ specificity; receptor; cerebral cortex; molecular weight; brain stem; receptor binding; tumor necrosis factor; receptors, cell surface; receptors, tumor necrosis factor; thalamus; basal ganglia; priority journal; article
Journal Title: Biochemical and Biophysical Research Communications
Volume: 181
Issue: 3
ISSN: 0006-291X
Publisher: Elsevier Science, Inc.  
Date Published: 1991-12-31
Start Page: 1532
End Page: 1538
Language: English
DOI: 10.1016/0006-291x(91)92113-x
PUBMED: 1662500
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026341950&doi=10.1016%2f0006-291X%2891%2992113-X&partnerID=40&md5=fe2f5e793a9f3ba2803c99e90239b642
Notes: Article -- Source: Scopus
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MSK Authors
  1. Gavril W Pasternak
    414 Pasternak
  2. David B. Donner
    29 Donner
  3. George P. Brown
    16 Brown
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