Acquired cyclic haematopoiesis associated with a radiation-induced chromosomal abnormality with clonal, morphologically normal circulating leucocytes Journal Article

  

Authors:	Crown, J. P.; Jhanwar, S.; Haimi, J.; Andreef, M.; Gee, T.
Article Title:	Acquired cyclic haematopoiesis associated with a radiation-induced chromosomal abnormality with clonal, morphologically normal circulating leucocytes
Abstract:	A 62-year-old male with a history of vesical carcinoma treated with pelvic radiotherapy and cystectomy developed intermittent fevers associated with oral ulcers and neutropenia. Serial blood counts revealed cyclic haematopoiesis, with periodic neutropenia, lymphocytopenia, monocytopenia and thrombocytopenia. Bone marrow examination revealed intermittent hypoplasia without myelodysplasia or leukaemia. Marrow karyotype revealed a clonal chromosomal abnormality which included trisomy 8 and absence of the Y chromosome. We also provide evidence of spontaneous differentiation of the clonal marrow cells to mature leucocytes.
Keywords:	adult; neutropenia; case report; thrombocytopenia; cell differentiation; radiation injury; lymphocytopenia; chromosome aberration; hematopoiesis; bone marrow cell; blood cell count; bladder carcinoma; karyotype; leukocyte; y chromosome; chromosome deletion y; trisomy 8; myelodysplasia; hypoplasia; human; male; priority journal; article; chromosomal abnormality; cyclic haematopoiesis
Journal Title:	Acta Haematologica
Volume:	86
Issue:	2
ISSN:	0001-5792
Publisher:	S. Karger AG
Date Published:	1991-01-01
Start Page:	103
End Page:	106
Language:	English
DOI:	10.1159/000204813
PUBMED:	1950369
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026044213&doi=10.1159%2f000204813&partnerID=40&md5=59f327d249ade333f206a5dac005333c
Notes:	Author Michael Andreeff's last name is misspelled on the original publication -- Source: Scopus

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